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Prom1 prominin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60357, updated on 5-Jun-2021

Summary

Official Symbol
Prom1provided by RGD
Official Full Name
prominin 1provided by RGD
Primary source
RGD:69367
See related
Ensembl:ENSRNOG00000003098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prom; CD133
Summary
induces expression of 3-phosphate glyceraldehyde dehydrogenase (GAPDH); may play a role in glucose homeostasis [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 250.8), Kidney (RPKM 151.2) and 8 other tissues See more
Orthologs
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Genomic context

See Prom1 in Genome Data Viewer
Location:
14q21
Exon count:
30
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (66989545..67094534)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (71532321..71637400)

Chromosome 14 - NC_051349.1Genomic Context describing neighboring genes Neighboring gene transmembrane anterior posterior transformation 1 Neighboring gene uncharacterized LOC120096623 Neighboring gene U7 small nuclear RNA Neighboring gene fibroblast growth factor binding protein 1 Neighboring gene uncharacterized LOC120096624

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC156650

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actinin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor outer segment membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in prominosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in prominosome ISO
Inferred from Sequence Orthology
more info
 
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110137.1NP_001103607.1  prominin-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001103607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AY262731, BI286840, CB780214, EV765242
    UniProtKB/TrEMBL
    A0A0G2K044, Q7TSL4
    Related
    ENSRNOP00000071297.1, ENSRNOT00000082592.1
    Conserved Domains (1) summary
    pfam05478
    Location:18812
    Prominin
  2. NM_021751.2NP_068519.2  prominin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_068519.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF386758, BI286840, CB780214
    UniProtKB/TrEMBL
    Q91XN5
    Related
    ENSRNOP00000004231.7, ENSRNOT00000004231.6
    Conserved Domains (1) summary
    pfam05478
    Location:18812
    Prominin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051349.1 Reference mRatBN7.2 Primary Assembly

    Range
    66989545..67094534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092362.1XP_038948290.1  prominin-1 isoform X1

    Conserved Domains (1) summary
    pfam05478
    Location:18821
    Prominin
  2. XM_008770211.3XP_008768433.1  prominin-1 isoform X1

    See identical proteins and their annotated locations for XP_008768433.1

    UniProtKB/TrEMBL
    A0A0G2JWD0
    Related
    ENSRNOP00000069832.1
    Conserved Domains (1) summary
    pfam05478
    Location:18821
    Prominin
  3. XM_039092361.1XP_038948289.1  prominin-1 isoform X1

    Conserved Domains (1) summary
    pfam05478
    Location:18821
    Prominin
  4. XM_039092364.1XP_038948292.1  prominin-1 isoform X3

    Conserved Domains (1) summary
    pfam05478
    Location:18812
    Prominin
  5. XM_039092366.1XP_038948294.1  prominin-1 isoform X5

    Conserved Domains (1) summary
    pfam05478
    Location:18821
    Prominin
  6. XM_039092363.1XP_038948291.1  prominin-1 isoform X2

    Conserved Domains (1) summary
    pfam05478
    Location:18821
    Prominin
  7. XM_039092367.1XP_038948295.1  prominin-1 isoform X6

    Conserved Domains (1) summary
    pfam05478
    Location:18821
    Prominin
  8. XM_039092365.1XP_038948293.1  prominin-1 isoform X4

    Conserved Domains (1) summary
    pfam05478
    Location:18805
    Prominin
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