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Ensa endosulfine alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 60334, updated on 21-Jul-2018

Summary

Official Symbol
Ensaprovided by RGD
Official Full Name
endosulfine alphaprovided by RGD
Primary source
RGD:62007
See related
Ensembl:ENSRNOG00000048617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may mediate insulin secretion through interaction with the pancreatic beta-cell ATP-sensitive potassium (K(ATP)) channel [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 459.1), Muscle (RPKM 435.8) and 9 other tissues See more
Orthologs

Genomic context

See Ensa in Genome Data Viewer
Location:
2q34
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197752544..197759882)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (217239490..217246148)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene HORMA domain containing 1 Neighboring gene 40S ribosomal protein S27-like Neighboring gene golgi phosphoprotein 3-like Neighboring gene MCL1, BCL2 family apoptosis regulator Neighboring gene ADAMTS-like 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
phosphatase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
potassium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
potassium channel regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphatase 2A binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alpha-endosulfine
Names
ARPP-19e

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033974.2NP_001029146.1  alpha-endosulfine isoform 1

    See identical proteins and their annotated locations for NP_001029146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AABR07012575, BC059135
    UniProtKB/Swiss-Prot
    P60841
    Related
    ENSRNOP00000070245.1, ENSRNOT00000079196.1
    Conserved Domains (1) summary
    pfam04667
    Location:3386
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
  2. NM_021842.3NP_068614.1  alpha-endosulfine isoform 2

    See identical proteins and their annotated locations for NP_068614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and a different 3' terminal exon compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AABR07012575, CB812628
    UniProtKB/Swiss-Prot
    P60841
    Related
    ENSRNOP00000063946.1, ENSRNOT00000075511.2
    Conserved Domains (1) summary
    pfam04667
    Location:33108
    Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    197752544..197759882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    175716326..175723664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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