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Wbp11 WW domain binding protein 11 [ Mus musculus (house mouse) ]

Gene ID: 60321, updated on 8-Dec-2022

Summary

Official Symbol
Wbp11provided by MGI
Official Full Name
WW domain binding protein 11provided by MGI
Primary source
MGI:MGI:1891823
See related
Ensembl:ENSMUSG00000030216 AllianceGenome:MGI:1891823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npwbp; SIPP1; D6Wsu113e; 2510026P17Rik
Summary
Enables protein phosphatase regulator activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nuclear speck. Is expressed in several structures, including blood; embryo ectoderm; embryo mesenchyme; extraembryonic component; and heart. Orthologous to human WBP11 (WW domain binding protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 80.0), CNS E11.5 (RPKM 24.0) and 28 other tissues See more
Orthologs
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Genomic context

See Wbp11 in Genome Data Viewer
Location:
6 G1; 6 66.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136790652..136805214, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136813654..136828216, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene H4 histone 16 Neighboring gene H2J.A histone Neighboring gene cDNA sequence BC049715 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene ADP-ribosyltransferase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WW domain-binding protein 11
Names
Npw38-binding protein
WBP-11
splicing factor that interacts with PQBP-1 and PP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021714.4NP_068360.4  WW domain-binding protein 11

    See identical proteins and their annotated locations for NP_068360.4

    Status: VALIDATED

    Source sequence(s)
    AC122804, AK041079
    Consensus CDS
    CCDS20655.1
    UniProtKB/Swiss-Prot
    Q8VDI0, Q923D5
    Related
    ENSMUSP00000112213.2, ENSMUST00000116514.4
    Conserved Domains (1) summary
    pfam09429
    Location:1292
    Wbp11; WW domain binding protein 11

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    136790652..136805214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321693.1XP_017177182.1  WW domain-binding protein 11 isoform X1

    UniProtKB/Swiss-Prot
    Q8VDI0, Q923D5
    Conserved Domains (1) summary
    pfam09429
    Location:1292
    Wbp11; WW domain binding protein 11
  2. XM_030255522.1XP_030111382.1  WW domain-binding protein 11 isoform X1

    UniProtKB/Swiss-Prot
    Q8VDI0
    Conserved Domains (1) summary
    pfam09429
    Location:1292
    Wbp11; WW domain binding protein 11