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RLF RLF zinc finger [ Homo sapiens (human) ]

Gene ID: 6018, updated on 20-Dec-2019

Summary

Official Symbol
RLFprovided by HGNC
Official Full Name
RLF zinc fingerprovided by HGNC
Primary source
HGNC:HGNC:10025
See related
Ensembl:ENSG00000117000 MIM:180610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZN-15L; ZNF292L
Expression
Ubiquitous expression in bone marrow (RPKM 13.7), testis (RPKM 7.9) and 25 other tissues See more
Orthologs

Genomic context

See RLF in Genome Data Viewer
Location:
1p34.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (40161387..40240921)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40627041..40706593)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OAZ1 pseudogene 1 Neighboring gene uncharacterized LOC105378671 Neighboring gene RNA, U6 small nuclear 1237, pseudogene Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene zinc metallopeptidase STE24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular rearranged L-myc fusion protein (RLF) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA integration IDA
Inferred from Direct Assay
more info
PubMed 
chromosome organization IDA
Inferred from Direct Assay
more info
PubMed 
chromosome organization NAS
Non-traceable Author Statement
more info
PubMed 
histone H3-K4 monomethylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of DNA methylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
zinc finger protein Rlf
Names
Zn-15 related
rearranged L-myc fusion gene protein
rearranged L-myc fusion sequence
zn-15-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012421.4NP_036553.2  zinc finger protein Rlf

    See identical proteins and their annotated locations for NP_036553.2

    Status: VALIDATED

    Source sequence(s)
    BC113666, BM542854
    Consensus CDS
    CCDS448.1
    UniProtKB/Swiss-Prot
    Q13129
    Related
    ENSP00000361857.4, ENST00000372771.5
    Conserved Domains (2) summary
    COG5236
    Location:645832
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:716736
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    40161387..40240921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002016.2XP_016857505.1  zinc finger protein Rlf isoform X1

    Conserved Domains (2) summary
    COG5236
    Location:429616
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017002017.2XP_016857506.1  zinc finger protein Rlf isoform X2

  3. XM_017002018.2XP_016857507.1  zinc finger protein Rlf isoform X3

    Conserved Domains (2) summary
    COG5236
    Location:256443
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
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