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RING1 ring finger protein 1 [ Homo sapiens (human) ]

Gene ID: 6015, updated on 7-Jun-2020

Summary

Official Symbol
RING1provided by HGNC
Official Full Name
ring finger protein 1provided by HGNC
Primary source
HGNC:HGNC:10018
See related
Ensembl:ENSG00000204227 MIM:602045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF1; RING1A
Summary
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 22.9), ovary (RPKM 22.0) and 25 other tissues See more
Orthologs

Genomic context

See RING1 in Genome Data Viewer
Location:
6p21.32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (33208500..33212716)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33176286..33180499)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 17-beta dehydrogenase 8 Neighboring gene microRNA 219a-1 Neighboring gene zinc finger protein 70 pseudogene 1 Neighboring gene uncharacterized LOC105375022

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
histone H2A monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H2A monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of G0 to G1 transition TAS
Traceable Author Statement
more info
 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PRC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
sex chromatin IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RING1
Names
RING-type E3 ubiquitin transferase RING1
polycomb complex protein RING1
really interesting new gene 1 protein
NP_002922.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002931.4NP_002922.2  E3 ubiquitin-protein ligase RING1

    See identical proteins and their annotated locations for NP_002922.2

    Status: REVIEWED

    Source sequence(s)
    AL645940, BC051866, BI259576
    Consensus CDS
    CCDS34424.1
    UniProtKB/Swiss-Prot
    Q06587
    UniProtKB/TrEMBL
    A0A1U9X8F2
    Related
    ENSP00000363787.4, ENST00000374656.5
    Conserved Domains (2) summary
    pfam16207
    Location:282400
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16739
    Location:4790
    RING-HC_RING1; RING finger, HC subclass, found in really interesting new gene 1 protein (RING1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    33208500..33212716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    4620001..4624217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    4451999..4456215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    4627977..4632193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    4644453..4648669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    4402908..4407124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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