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RLN1 relaxin 1 [ Homo sapiens (human) ]

Gene ID: 6013, updated on 7-Jun-2020

Summary

Official Symbol
RLN1provided by HGNC
Official Full Name
relaxin 1provided by HGNC
Primary source
HGNC:HGNC:10026
See related
Ensembl:ENSG00000107018 MIM:179730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2
Summary
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]
Expression
Biased expression in prostate (RPKM 8.0) and testis (RPKM 0.2) See more
Orthologs

Genomic context

See RLN1 in Genome Data Viewer
Location:
9p24.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (5299864..5340915, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5307637..5339873, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Janus kinase 2 Neighboring gene insulin like 6 Neighboring gene uncharacterized LOC107987044 Neighboring gene immunoglobulin heavy constant epsilon P2 (pseudogene) Neighboring gene INSL4 promoter region Neighboring gene insulin like 4 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 31 Neighboring gene relaxin 2 Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene ring finger protein 152 pseudogene 1 Neighboring gene CD274 molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
female pregnancy NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
prorelaxin H1
Names
preprorelaxin H1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006911.4NP_008842.1  prorelaxin H1 preproprotein

    See identical proteins and their annotated locations for NP_008842.1

    Status: REVIEWED

    Source sequence(s)
    AI363233, AL135786, AV742436, BC005956
    Consensus CDS
    CCDS6462.1
    UniProtKB/Swiss-Prot
    P04808
    Related
    ENSP00000223862.1, ENST00000223862.2
    Conserved Domains (1) summary
    cd04365
    Location:31185
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    5299864..5340915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447637.1XP_024303405.1  prorelaxin H1 isoform X1

    Conserved Domains (1) summary
    cd04365
    Location:15169
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  2. XM_024447640.1XP_024303408.1  prorelaxin H1 isoform X7

    Conserved Domains (1) summary
    cd04365
    Location:61100
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  3. XM_024447638.1XP_024303406.1  prorelaxin H1 isoform X2

    Conserved Domains (1) summary
    cd04365
    Location:4158
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  4. XM_024447639.1XP_024303407.1  prorelaxin H1 isoform X7

    Conserved Domains (1) summary
    cd04365
    Location:61100
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  5. XM_024447641.1XP_024303409.1  prorelaxin H1 isoform X7

    Conserved Domains (1) summary
    cd04365
    Location:61100
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  6. XM_017015010.1XP_016870499.1  prorelaxin H1 isoform X6

  7. XM_017015008.1XP_016870497.1  prorelaxin H1 isoform X4

  8. XM_017015007.1XP_016870496.1  prorelaxin H1 isoform X3

    Conserved Domains (1) summary
    cd04365
    Location:3154
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  9. XM_024447644.1XP_024303412.1  prorelaxin H1 isoform X8

    Conserved Domains (1) summary
    cd04365
    Location:6099
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  10. XM_024447643.1XP_024303411.1  prorelaxin H1 isoform X8

    Conserved Domains (1) summary
    cd04365
    Location:6099
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  11. XM_024447642.1XP_024303410.1  prorelaxin H1 isoform X8

    Related
    ENST00000487557.2
    Conserved Domains (1) summary
    cd04365
    Location:6099
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  12. XM_024447645.1XP_024303413.1  prorelaxin H1 isoform X8

    Conserved Domains (1) summary
    cd04365
    Location:6099
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
  13. XM_017015009.1XP_016870498.1  prorelaxin H1 isoform X5

    UniProtKB/Swiss-Prot
    P04808
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