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RHEB Ras homolog, mTORC1 binding [ Homo sapiens (human) ]

Gene ID: 6009, updated on 8-Aug-2021

Summary

Official Symbol
RHEBprovided by HGNC
Official Full Name
Ras homolog, mTORC1 bindingprovided by HGNC
Primary source
HGNC:HGNC:10011
See related
Ensembl:ENSG00000106615 MIM:601293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RHEB2
Summary
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 38.1), brain (RPKM 36.3) and 25 other tissues See more
Orthologs
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Genomic context

See RHEB in Genome Data Viewer
Location:
7q36.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (151466012..151519895, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151163098..151216981, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 3907 Neighboring gene crystallin gamma N Neighboring gene RNA, 7SL, cytoplasmic 76, pseudogene Neighboring gene eukaryotic translation termination factor 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 3106 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 2 Neighboring gene VISTA enhancer hs2193

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111559

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GDP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
 
enables magnesium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in lysosomal membrane TAS
Traceable Author Statement
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
located_in postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GTP-binding protein Rheb
Names
Ras homolog enriched in brain 2
NP_005605.1
XP_011514759.1
XP_024302622.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005614.4NP_005605.1  GTP-binding protein Rheb

    See identical proteins and their annotated locations for NP_005605.1

    Status: REVIEWED

    Source sequence(s)
    BC016155, BG702213, BM670621, DA475169, Z29677
    Consensus CDS
    CCDS5927.1
    UniProtKB/Swiss-Prot
    Q15382
    UniProtKB/TrEMBL
    A0A090N900
    Related
    ENSP00000262187.5, ENST00000262187.10
    Conserved Domains (1) summary
    cd04137
    Location:6184
    RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    151466012..151519895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516457.2XP_011514759.1  GTP-binding protein Rheb isoform X1

    See identical proteins and their annotated locations for XP_011514759.1

    Conserved Domains (1) summary
    cd04137
    Location:1173
    RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase
  2. XM_024446854.1XP_024302622.1  GTP-binding protein Rheb isoform X1

    Conserved Domains (1) summary
    cd04137
    Location:1173
    RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase
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