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RHAG Rh associated glycoprotein [ Homo sapiens (human) ]

Gene ID: 6005, updated on 8-Jul-2021

Summary

Official Symbol
RHAGprovided by HGNC
Official Full Name
Rh associated glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:10006
See related
Ensembl:ENSG00000112077 MIM:180297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OHS; RH2; OHST; RHNR; Rh50; CD241; RH50A; Rh50GP; SLC42A1
Summary
The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009]
Expression
Restricted expression toward bone marrow (RPKM 40.5) See more
Orthologs
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Genomic context

See RHAG in Genome Data Viewer
Location:
6p12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (49605175..49636874, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49572888..49604552, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromosome 6 open reading frame 141 Neighboring gene cytochrome P450 family 2 subfamily AC member 1, pseudogene Neighboring gene GATA motif-containing MPRA enhancer 217 Neighboring gene cysteine rich secretory protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in ammonium transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ammonium transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ammonium transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ammonium transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in bicarbonate transport TAS
Traceable Author Statement
more info
 
involved_in carbon dioxide transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in carbon dioxide transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in inorganic cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in multicellular organismal iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ammonium transporter Rh type A
Names
Rh 50 glycoprotein
Rhesus associated polypeptide, 50-KD
Rhesus blood group-associated glycoprotein
erythrocyte membrane glycoprotein Rh50
erythrocyte plasma membrane 50 kDa glycoprotein
mutant Rh associated glycoprotein
rh family type A glycoprotein
rh type A glycoprotein
rhesus blood group family type A glycoprotein
rhesus blood group-associated ammonia channel
truncated Rh-associated glycoprotein
truncated RhAG glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011704.1 RefSeqGene

    Range
    5001..36700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_822

mRNA and Protein(s)

  1. NM_000324.3NP_000315.2  ammonium transporter Rh type A

    See identical proteins and their annotated locations for NP_000315.2

    Status: REVIEWED

    Source sequence(s)
    BC012605, X64594
    Consensus CDS
    CCDS4927.1
    UniProtKB/Swiss-Prot
    Q02094
    UniProtKB/TrEMBL
    Q96E98
    Related
    ENSP00000360217.4, ENST00000371175.10
    Conserved Domains (1) summary
    pfam00909
    Location:15402
    Ammonium_transp; Ammonium Transporter Family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    49605175..49636874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514788.1XP_011513090.1  ammonium transporter Rh type A isoform X1

    Conserved Domains (1) summary
    cl03012
    Location:15213
    Ammonium_transp; Ammonium Transporter Family
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