Format

Send to:

Choose Destination

RGS4 regulator of G protein signaling 4 [ Homo sapiens (human) ]

Gene ID: 5999, updated on 8-Dec-2018

Summary

Official Symbol
RGS4provided by HGNC
Official Full Name
regulator of G protein signaling 4provided by HGNC
Primary source
HGNC:HGNC:10000
See related
Ensembl:ENSG00000117152 MIM:602516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGP4; SCZD9
Summary
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 67.5), adrenal (RPKM 15.7) and 1 other tissue See more
Orthologs

Genomic context

See RGS4 in Genome Data Viewer
Location:
1q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (163068606..163076802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163038396..163046592)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene uncharacterized LOC107985223 Neighboring gene RGS4-RGS5 intergenic ENCODE-defined enhancer Neighboring gene uncharacterized LOC101928404 Neighboring gene regulator of G protein signaling 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of regulator of G-protein signaling 4 (RGS4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (z) signalling events, organism-specific biosystemThe heterotrimeric G protein Gz, is a member of the Gi family. Unlike other Gi family members it lacks an ADP ribosylation site cysteine four residues from the carboxyl terminus and is thus pertussis...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2124, MGC60244, DKFZp761F1924

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
dorsal root ganglion development IEA
Inferred from Electronic Annotation
more info
 
inactivation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glycine import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
negative regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of actin filament organization IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 4
Names
schizophrenia disorder 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023312.1 RefSeqGene

    Range
    5001..13197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001102445.2NP_001095915.1  regulator of G-protein signaling 4 isoform 1

    See identical proteins and their annotated locations for NP_001095915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL583850, DC334933, DQ346664
    Consensus CDS
    CCDS44270.1
    UniProtKB/Swiss-Prot
    P49798
    Related
    ENSP00000397181.2, ENST00000421743.6
    Conserved Domains (1) summary
    cd08714
    Location:160273
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
  2. NM_001113380.1NP_001106851.1  regulator of G-protein signaling 4 isoform 3

    See identical proteins and their annotated locations for NP_001106851.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL583850, EF054877
    Consensus CDS
    CCDS44272.1
    UniProtKB/Swiss-Prot
    P49798
    Related
    ENSP00000356882.3, ENST00000367906.7
    Conserved Domains (1) summary
    cd08714
    Location:45158
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein
  3. NM_001113381.1NP_001106852.1  regulator of G-protein signaling 4 isoform 4

    See identical proteins and their annotated locations for NP_001106852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an internal coding exon in the 3' region, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK093959, AL583850, DA660695
    Consensus CDS
    CCDS44271.1
    UniProtKB/Swiss-Prot
    P49798
    Related
    ENSP00000356884.4, ENST00000367908.8
  4. NM_005613.5NP_005604.1  regulator of G-protein signaling 4 isoform 2

    See identical proteins and their annotated locations for NP_005604.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL583850, DC318279, DQ346663
    Consensus CDS
    CCDS1243.1
    UniProtKB/Swiss-Prot
    P49798
    UniProtKB/TrEMBL
    A0A024R909
    Related
    ENSP00000356885.6, ENST00000367909.10
    Conserved Domains (1) summary
    cd08714
    Location:63176
    RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    163068606..163076802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center