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RENBP renin binding protein [ Homo sapiens (human) ]

Gene ID: 5973, updated on 2-Oct-2018

Summary

Official Symbol
RENBPprovided by HGNC
Official Full Name
renin binding proteinprovided by HGNC
Primary source
HGNC:HGNC:9959
See related
Ensembl:ENSG00000102032 MIM:312420; Vega:OTTHUMG00000024224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBP; RNBP
Summary
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 29.7), spleen (RPKM 23.5) and 18 other tissues See more
Orthologs

Genomic context

See RENBP in Genome Data Viewer
Location:
Xq28
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (153935263..153944780, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153200722..153210232, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 4 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene host cell factor C1 Neighboring gene HCFC1 antisense RNA 1 Neighboring gene transmembrane protein 187 Neighboring gene microRNA 3202-1 Neighboring gene microRNA 3202-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
N-acylglucosamine 2-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acylglucosamine 2-epimerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
N-acylglucosamine 2-epimerase activity TAS
Traceable Author Statement
more info
 
endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
peptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylmannosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylneuraminate catabolic process IEA
Inferred from Electronic Annotation
more info
 
N-acetylneuraminate catabolic process TAS
Traceable Author Statement
more info
PubMed 
UDP-N-acetylglucosamine biosynthetic process TAS
Traceable Author Statement
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
N-acylglucosamine 2-epimerase
Names
AGE
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
NP_002901.2
XP_016885187.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012522.1 RefSeqGene

    Range
    5001..14511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002910.5NP_002901.2  N-acylglucosamine 2-epimerase

    See identical proteins and their annotated locations for NP_002901.2

    Status: REVIEWED

    Source sequence(s)
    AK298125, BC015558, D10232, U52112
    Consensus CDS
    CCDS14738.2
    UniProtKB/Swiss-Prot
    P51606
    Related
    ENSP00000377303.3, OTTHUMP00000025998, ENST00000393700.7, OTTHUMT00000061103
    Conserved Domains (1) summary
    cd00249
    Location:14407
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    153935263..153944780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029698.1XP_016885187.1  N-acylglucosamine 2-epimerase isoform X1

    UniProtKB/Swiss-Prot
    P51606
    Conserved Domains (1) summary
    cd00249
    Location:4397
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...
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