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RCN1 reticulocalbin 1 [ Homo sapiens (human) ]

Gene ID: 5954, updated on 6-Sep-2021

Summary

Official Symbol
RCN1provided by HGNC
Official Full Name
reticulocalbin 1provided by HGNC
Primary source
HGNC:HGNC:9934
See related
Ensembl:ENSG00000049449 MIM:602735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCN; RCAL; PIG20; HEL-S-84
Summary
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in placenta (RPKM 69.9), urinary bladder (RPKM 61.7) and 24 other tissues See more
Orthologs
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Genomic context

See RCN1 in Genome Data Viewer
Location:
11p13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (32091074..32105722)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32112620..32127268)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928385 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 5 Neighboring gene thioesterase superfamily member 7, pseudogene Neighboring gene uncharacterized LOC107984322 Neighboring gene small nucleolar RNA, H/ACA box 88

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RCN1; predicted interaction to be within the endoplasmic reticulum PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with reticulocalbin 1, EF-hand calcium binding domain (RCN1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37041, FLJ55835

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
reticulocalbin-1
Names
epididymis secretory protein Li 84
proliferation-inducing gene 20
reticulocalbin 1, EF-hand calcium binding domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002901.4NP_002892.1  reticulocalbin-1 precursor

    See identical proteins and their annotated locations for NP_002892.1

    Status: REVIEWED

    Source sequence(s)
    AK126419, BC010120, BG109024, BP253627, CA449220
    Consensus CDS
    CCDS7876.1
    UniProtKB/Swiss-Prot
    Q15293
    UniProtKB/TrEMBL
    V9HW95
    Related
    ENSP00000054950.4, ENST00000054950.4
    Conserved Domains (1) summary
    cd16229
    Location:48314
    EFh_CREC_RCN1; EF-hand, calcium binding motif, found in reticulocalbin-1 (RCN-1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    32091074..32105722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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