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hao2 hydroxyacid oxidase 2 (long chain) [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 595012, updated on 4-Jan-2025

Summary

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Official Symbol
hao2provided by Xenbase
Official Full Name
hydroxyacid oxidase 2 (long chain)provided by Xenbase
Primary source
Xenbase:XB-GENE-979509
See related
Ensembl:ENSXETG00000018082 AllianceGenome:Xenbase:XB-GENE-979509
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable (S)-2-hydroxy-acid oxidase activity. Predicted to be located in peroxisome. Predicted to be active in peroxisomal matrix. Orthologous to human HAO2 (hydroxyacid oxidase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See hao2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (2059386..2068859, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) Unplaced Scaffold NW_016684427.1 (13..8984)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene phospholipase A1 member A Neighboring gene 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Neighboring gene tryptophanyl tRNA synthetase 2, mitochondrial Neighboring gene T-box 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC108441

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables (S)-2-hydroxy-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-Hydroxyacid oxidase 2; hydroxyacid oxidase 2
NP_001025624.1
XP_012812532.1
XP_012812533.1
XP_012812534.1
XP_012812535.1
XP_012812536.1
XP_012812538.1
XP_012812539.1
XP_012812540.1
XP_012812541.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030453.1 → NP_001025624.1  2-Hydroxyacid oxidase 2

    See identical proteins and their annotated locations for NP_001025624.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091092
    UniProtKB/TrEMBL
    A0A6I8QUQ7, A0A803K923, Q5BKF6
    Conserved Domains (1) summary
    pfam01070
    Location:14 → 352
    FMN_dh; FMN-dependent dehydrogenase

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    2059386..2068859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012957085.3 → XP_012812539.1  hydroxyacid oxidase 2 isoform X3

    See identical proteins and their annotated locations for XP_012812539.1

    UniProtKB/TrEMBL
    A0A6I8QUQ7, A0A803K923, Q5BKF6
    Related
    ENSXETP00000112440.1, ENSXETT00000106639.1
    Conserved Domains (1) summary
    pfam01070
    Location:14 → 352
    FMN_dh; FMN-dependent dehydrogenase

  2. XM_012957082.3 → XP_012812536.1  hydroxyacid oxidase 2 isoform X3

    See identical proteins and their annotated locations for XP_012812536.1

    UniProtKB/TrEMBL
    A0A6I8QUQ7, A0A803K923, Q5BKF6
    Related
    ENSXETP00000107145.1, ENSXETT00000111969.1
    Conserved Domains (1) summary
    pfam01070
    Location:14 → 352
    FMN_dh; FMN-dependent dehydrogenase

  3. XM_012957086.3 → XP_012812540.1  hydroxyacid oxidase 2 isoform X3

    See identical proteins and their annotated locations for XP_012812540.1

    UniProtKB/TrEMBL
    A0A6I8QUQ7, A0A803K923, Q5BKF6
    Related
    ENSXETP00000115115.1, ENSXETT00000114347.1
    Conserved Domains (1) summary
    pfam01070
    Location:14 → 352
    FMN_dh; FMN-dependent dehydrogenase

  4. XM_012957080.3 → XP_012812534.1  hydroxyacid oxidase 2 isoform X3

    See identical proteins and their annotated locations for XP_012812534.1

    UniProtKB/TrEMBL
    A0A6I8QUQ7, A0A803K923, Q5BKF6
    Related
    ENSXETP00000039226.5, ENSXETT00000039226.5
    Conserved Domains (1) summary
    pfam01070
    Location:14 → 352
    FMN_dh; FMN-dependent dehydrogenase

  5. XM_012957079.3 → XP_012812533.1  hydroxyacid oxidase 2 isoform X2

    UniProtKB/TrEMBL
    A0A803K923, A0A8J0SCW0
    Conserved Domains (2) summary
    cd02809
    Location:31 → 372
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:38 → 376
    FMN_dh; FMN-dependent dehydrogenase

  6. XM_012957078.3 → XP_012812532.1  hydroxyacid oxidase 2 isoform X1

    See identical proteins and their annotated locations for XP_012812532.1

    UniProtKB/TrEMBL
    A0A1B8XVB0, A0A803K923
    Related
    ENSXETP00000112455.1, ENSXETT00000114655.1
    Conserved Domains (2) summary
    cd02809
    Location:32 → 373
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:39 → 377
    FMN_dh; FMN-dependent dehydrogenase

  7. XM_012957084.2 → XP_012812538.1  hydroxyacid oxidase 2 isoform X3

    See identical proteins and their annotated locations for XP_012812538.1

    UniProtKB/TrEMBL
    A0A6I8QUQ7, A0A803K923, Q5BKF6
    Conserved Domains (1) summary
    pfam01070
    Location:14 → 352
    FMN_dh; FMN-dependent dehydrogenase

  8. XM_012957081.3 → XP_012812535.1  hydroxyacid oxidase 2 isoform X1

    See identical proteins and their annotated locations for XP_012812535.1

    UniProtKB/TrEMBL
    A0A1B8XVB0, A0A803K923
    Related
    ENSXETP00000115106.1, ENSXETT00000110771.1
    Conserved Domains (2) summary
    cd02809
    Location:32 → 373
    alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...
    pfam01070
    Location:39 → 377
    FMN_dh; FMN-dependent dehydrogenase

  9. XM_012957087.3 → XP_012812541.1  hydroxyacid oxidase 2 isoform X3

    See identical proteins and their annotated locations for XP_012812541.1

    UniProtKB/TrEMBL
    A0A6I8QUQ7, A0A803K923, Q5BKF6
    Conserved Domains (1) summary
    pfam01070
    Location:14 → 352
    FMN_dh; FMN-dependent dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version

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