fgb fibrinogen beta chain [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: fgbprovided by Xenbase
Official Full Name: fibrinogen beta chainprovided by Xenbase
Primary source: Xenbase:XB-GENE-483216
See related: Ensembl:ENSXETG00000022431 AllianceGenome:Xenbase:XB-GENE-483216
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in blood coagulation; fibrinolysis; and positive regulation of heterotypic cell-cell adhesion. Predicted to act upstream of or within platelet activation and protein polymerization. Predicted to be located in extracellular region. Predicted to be part of fibrinogen complex. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (54538968..54547392, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (45298451..45305601, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation, common pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in fibrinolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet activation	IEA Inferred from Electronic Annotation more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of heterotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein polymerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of fibrinogen complex	IBA Inferred from Biological aspect of Ancestor more info
part_of fibrinogen complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibrinogen beta chain

Names: B fibrinopeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114490.1 → NP_001107962.1 fibrinogen beta chain precursor

See identical proteins and their annotated locations for NP_001107962.1

Status: PROVISIONAL

Source sequence(s)

BC158991

UniProtKB/TrEMBL

B0JZ09, Q505I1

Related

ENSXETP00000048547.4, ENSXETT00000048547.5

Conserved Domains (2) summary

pfam08702
Location:93 → 235

Fib_alpha; Fibrinogen alpha/beta chain family

cl00085
Location:238 → 487

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...