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CPLX3 complexin 3 [ Homo sapiens (human) ]

Gene ID: 594855, updated on 1-Aug-2020

Summary

Official Symbol
CPLX3provided by HGNC
Official Full Name
complexin 3provided by HGNC
Primary source
HGNC:HGNC:27652
See related
Ensembl:ENSG00000213578 MIM:609585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPXIII; CPX-III; Nbla11589
Expression
Biased expression in prostate (RPKM 58.8), spleen (RPKM 33.7) and 3 other tissues See more
Orthologs

Genomic context

See CPLX3 in Genome Data Viewer
Location:
15q24.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74826627..74831802)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75118951..75124136)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene C-terminal Src kinase Neighboring gene microRNA 4513 Neighboring gene lectin, mannose binding 1 like Neighboring gene uncharacterized LOC105370897 Neighboring gene unc-51 like kinase 3 Neighboring gene microRNA 6882 Neighboring gene secretory carrier membrane protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
NHGRI GWA Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: LMAN1L

Homology

Clone Names

  • FLJ00167, FLJ00250, FLJ13993, DKFZp434E1719

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter transporter activity IEA
Inferred from Electronic Annotation
more info
 
syntaxin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
insulin secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic vesicle fusion to presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
response to stimulus IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anchored component of presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
anchored component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
photoreceptor ribbon synapse IEA
Inferred from Electronic Annotation
more info
 
terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
complexin-3
Names
CPX III
complexin III
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030005.3NP_001025176.1  complexin-3

    See identical proteins and their annotated locations for NP_001025176.1

    Status: VALIDATED

    Source sequence(s)
    AC091230, AK024055, AU253913, BC018026
    Consensus CDS
    CCDS32294.1
    UniProtKB/Swiss-Prot
    Q8WVH0
    Related
    ENSP00000378464.4, ENST00000395018.6
    Conserved Domains (1) summary
    pfam05835
    Location:1139
    Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74826627..74831802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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