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RBP2 retinol binding protein 2 [ Homo sapiens (human) ]

Gene ID: 5948, updated on 23-Nov-2021

Summary

Official Symbol
RBP2provided by HGNC
Official Full Name
retinol binding protein 2provided by HGNC
Primary source
HGNC:HGNC:9920
See related
Ensembl:ENSG00000114113 MIM:180280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRBP2; RBPC2; CRBPII; CRABP-II
Summary
This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]
Annotation information
Note: RBP2 (Gene ID: 5948) and KDM5A (Gene ID: 5927) share the RBP2 symbol/alias in common. RBP2 is a widely used alternative name for lysine demethylase 5A (KDM5A), which can be confused with the official symbol for retinol binding protein 2 (RBP2). [03 Jul 2018]
Expression
Biased expression in duodenum (RPKM 1065.7) and small intestine (RPKM 769.4) See more
Orthologs
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Genomic context

See RBP2 in Genome Data Viewer
Location:
3q23
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (139452884..139476516, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (139171726..139195358, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3993 Neighboring gene mitochondrial ribosomal protein S22 Neighboring gene COPI coat complex subunit beta 2 Neighboring gene COPB2 divergent transcript Neighboring gene actin gamma 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 7279 Neighboring gene retinol binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables retinal binding IEA
Inferred from Electronic Annotation
more info
 
enables retinoid binding TAS
Traceable Author Statement
more info
PubMed 
enables retinol binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in epidermis development TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vitamin A metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
retinol-binding protein 2
Names
CRBP-II
cellular retinol-binding protein II
retinol binding protein 2, cellular

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004164.3NP_004155.2  retinol-binding protein 2

    See identical proteins and their annotated locations for NP_004155.2

    Status: REVIEWED

    Source sequence(s)
    AC097103, AW772327, BX282005
    Consensus CDS
    CCDS3109.1
    UniProtKB/Swiss-Prot
    P50120
    Related
    ENSP00000232217.2, ENST00000232217.6
    Conserved Domains (1) summary
    pfam00061
    Location:6122
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    139452884..139476516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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