Format

Send to:

Choose Destination

RBMY1A1 RNA binding motif protein Y-linked family 1 member A1 [ Homo sapiens (human) ]

Gene ID: 5940, updated on 11-Jun-2021

Summary

Official Symbol
RBMY1A1provided by HGNC
Official Full Name
RNA binding motif protein Y-linked family 1 member A1provided by HGNC
Primary source
HGNC:HGNC:9912
See related
Ensembl:ENSG00000234414 MIM:400006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBM; RBM1; RBM2; RBMY; YRRM1; YRRM2; RBMY1C
Summary
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein is thought to function as a splicing regulator during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]
Expression
Restricted expression toward testis (RPKM 10.4) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RBMY1A1 in Genome Data Viewer
Location:
Yq11.223
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (21534879..21559683)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (23696765..23711212)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein Y-linked family 1 member H, pseudogene Neighboring gene RNA binding motif protein Y-linked family 1 member B Neighboring gene testis-specific transcript, Y-linked 13 Neighboring gene elongin C pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with RNA binding motif protein, Y-linked, family 1, member A1 (RBMY1A1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC181956

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding motif protein, Y chromosome, family 1 member A1
Names
RNA-binding motif protein 2
RNA-binding motif protein, Y chromosome, family 1 member A1/C
Y chromosome RNA recognition motif 1
Y chromosome RNA recognition motif 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_004832.1 

    Range
    224219..238666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NG_012805.1 RefSeqGene

    Range
    4967..19414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320944.2NP_001307873.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    BC070298, BX119894, CB107177
    UniProtKB/Swiss-Prot
    P0DJD3
    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  2. NM_001320945.2NP_001307874.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    BC047768, CB107177
    UniProtKB/Swiss-Prot
    P0DJD3
    Conserved Domains (1) summary
    pfam08081
    Location:3478
    RBM1CTR; RBM1CTR (NUC064) family
  3. NM_005058.4NP_005049.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform 1

    See identical proteins and their annotated locations for NP_005049.1

    Status: REVIEWED

    Source sequence(s)
    BX119894, CB107177, X76059
    Consensus CDS
    CCDS14796.1
    UniProtKB/Swiss-Prot
    P0DJD3
    Related
    ENSP00000372154.2, ENST00000382707.6
    Conserved Domains (3) summary
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    21534879..21559683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531437.2XP_011529739.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform X1

    Conserved Domains (4) summary
    PHA02896
    Location:247362
    PHA02896; A-type inclusion like protein; Provisional
    COG0724
    Location:1189
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12382
    Location:785
    RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
    pfam08081
    Location:174218
    RBM1CTR; RBM1CTR (NUC064) family
  2. XM_017030060.1XP_016885549.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform X2

Support Center