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TMEM35A transmembrane protein 35A [ Homo sapiens (human) ]

Gene ID: 59353, updated on 22-Sep-2022

Summary

Official Symbol
TMEM35Aprovided by HGNC
Official Full Name
transmembrane protein 35Aprovided by HGNC
Primary source
HGNC:HGNC:25864
See related
Ensembl:ENSG00000126950 AllianceGenome:HGNC:25864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NACHO; TUF-1; TMEM35
Summary
Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 18.3), prostate (RPKM 12.0) and 12 other tissues See more
Orthologs
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Genomic context

See TMEM35A in Genome Data Viewer
Location:
Xq22.1
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (101078879..101096367)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99522299..99539787)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100333868..100351356)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 13A Neighboring gene tRNA methyltransferase 2 homolog B Neighboring gene U2 spliceosomal RNA Neighboring gene centromere protein I Neighboring gene YWHAQ pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetylcholine receptor regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
novel acetylcholine receptor chaperone
Names
nAChR regulator
nicotinic acetylcholine receptor regulator
transmembrane protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021637.3NP_067650.1  novel acetylcholine receptor chaperone

    See identical proteins and their annotated locations for NP_067650.1

    Status: VALIDATED

    Source sequence(s)
    AL109952, BC078658, BU736545
    Consensus CDS
    CCDS14478.1
    UniProtKB/Swiss-Prot
    Q53FP2, Q9H7Y3
    Related
    ENSP00000362021.4, ENST00000372930.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    101078879..101096367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    99522299..99539787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)