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TMEM35A transmembrane protein 35A [ Homo sapiens (human) ]

Gene ID: 59353, updated on 3-May-2025
Official Symbol
TMEM35Aprovided by HGNC
Official Full Name
transmembrane protein 35Aprovided by HGNC
Primary source
HGNC:HGNC:25864
See related
Ensembl:ENSG00000126950 AllianceGenome:HGNC:25864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NACHO; TUF-1; TMEM35
Summary
Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, May 2025]
Expression
Biased expression in brain (RPKM 18.3), prostate (RPKM 12.0) and 12 other tissues See more
Orthologs
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See TMEM35A in Genome Data Viewer
Location:
Xq22.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (101078879..101096367)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (99522299..99539787)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100333868..100351356)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 13A Neighboring gene ReSE screen-validated silencer GRCh37_chrX:100246331-100246526 Neighboring gene tRNA methyltransferase 2 homolog B Neighboring gene uncharacterized LOC124905285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29807 Neighboring gene centromere protein I Neighboring gene YWHAQ pseudogene 8

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ14084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetylcholine receptor regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine receptor regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
novel acetylcholine receptor chaperone
Names
nAChR regulator
nicotinic acetylcholine receptor regulator
transmembrane protein 35

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021637.3NP_067650.1  novel acetylcholine receptor chaperone

    See identical proteins and their annotated locations for NP_067650.1

    Status: VALIDATED

    Source sequence(s)
    AL109952, BC078658, BU736545
    Consensus CDS
    CCDS14478.1
    UniProtKB/Swiss-Prot
    Q53FP2, Q9H7Y3
    Related
    ENSP00000362021.4, ENST00000372930.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    101078879..101096367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    99522299..99539787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)