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LGR6 leucine rich repeat containing G protein-coupled receptor 6 [ Homo sapiens (human) ]

Gene ID: 59352, updated on 23-Nov-2021

Summary

Official Symbol
LGR6provided by HGNC
Official Full Name
leucine rich repeat containing G protein-coupled receptor 6provided by HGNC
Primary source
HGNC:HGNC:19719
See related
Ensembl:ENSG00000133067 MIM:606653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR; VTS20631
Summary
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 3.1), testis (RPKM 2.2) and 22 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See LGR6 in Genome Data Viewer
Location:
1q32.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (202193799..202319761)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202162927..202288889)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 7 Neighboring gene protein tyrosine phosphatase receptor type V, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5820 Neighboring gene uncharacterized LOC101929388 Neighboring gene protein phosphatase 1 regulatory subunit 12B Neighboring gene ubiquitin conjugating enzyme E2 T Neighboring gene CYCS pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
GeneReviews: Not available
Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human leucine-rich repeat containing G protein-coupled receptor 6 (LGR6) at amino acid residues 202-203 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14471

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bone regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 6
Names
gonadotropin receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017403.2NP_001017403.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001017403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB049405, AF088074, AL356953, BC047905, BM699180
    Consensus CDS
    CCDS30971.1
    UniProtKB/Swiss-Prot
    Q9HBX8
    Related
    ENSP00000356247.3, ENST00000367278.8
    Conserved Domains (5) summary
    smart00013
    Location:3468
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:131392
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:330344
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:7091
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:375434
    LRR_8; Leucine rich repeat
  2. NM_001017404.2NP_001017404.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform 3

    See identical proteins and their annotated locations for NP_001017404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF088074, AF190501, AL356953, BC047905
    Consensus CDS
    CCDS30972.1
    UniProtKB/Swiss-Prot
    Q9HBX8
    Related
    ENSP00000387869.2, ENST00000439764.2
    Conserved Domains (5) summary
    cd00116
    Location:29253
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:285298
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:2948
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:235276
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:49107
    LRR_8; Leucine rich repeat
  3. NM_021636.3NP_067649.2  leucine-rich repeat-containing G-protein coupled receptor 6 isoform 2

    See identical proteins and their annotated locations for NP_067649.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF088074, AL356953, AY358119, BC047905
    Consensus CDS
    CCDS1424.1
    UniProtKB/Swiss-Prot
    Q9HBX8
    Related
    ENSP00000255432.7, ENST00000255432.11
    Conserved Domains (4) summary
    cd00116
    Location:79340
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:278292
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:2039
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:323382
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    202193799..202319761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509839.2XP_011508141.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X3

    Conserved Domains (5) summary
    cd00116
    Location:88349
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:287310
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:2948
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:331371
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:143203
    LRR_8; Leucine rich repeat
  2. XM_017001996.1XP_016857485.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X4

  3. XM_011509838.2XP_011508140.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X2

    Conserved Domains (3) summary
    cd00116
    Location:186375
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:2948
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:308367
    LRR_8; Leucine rich repeat
  4. XM_011509840.2XP_011508142.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X5

    Conserved Domains (5) summary
    cd00116
    Location:42277
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:215229
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:2948
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:259300
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:260319
    LRR_8; Leucine rich repeat
  5. XM_005245404.3XP_005245461.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X1

    Conserved Domains (4) summary
    cd00116
    Location:88349
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:287301
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:2948
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:332391
    LRR_8; Leucine rich repeat
  6. XM_017001997.1XP_016857486.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X6

  7. XM_011509846.2XP_011508148.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X8

    See identical proteins and their annotated locations for XP_011508148.1

    Conserved Domains (3) summary
    cd00116
    Location:40245
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:2245
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:185244
    LRR_8; Leucine rich repeat
  8. XM_011509843.2XP_011508145.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X8

    See identical proteins and their annotated locations for XP_011508145.1

    Conserved Domains (3) summary
    cd00116
    Location:40245
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:2245
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:185244
    LRR_8; Leucine rich repeat
  9. XM_011509841.2XP_011508143.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X7

    Conserved Domains (5) summary
    cd00116
    Location:28258
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:290303
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3053
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:240281
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:241300
    LRR_8; Leucine rich repeat
  10. XM_011509842.2XP_011508144.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X8

    See identical proteins and their annotated locations for XP_011508144.1

    Conserved Domains (3) summary
    cd00116
    Location:40245
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:2245
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:185244
    LRR_8; Leucine rich repeat
  11. XM_011509844.2XP_011508146.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X9

    Conserved Domains (3) summary
    cd00116
    Location:10183
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:2447
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:116175
    LRR_8; Leucine rich repeat
  12. XM_017001998.1XP_016857487.1  leucine-rich repeat-containing G-protein coupled receptor 6 isoform X10

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