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ZNF350 zinc finger protein 350 [ Homo sapiens (human) ]

Gene ID: 59348, updated on 13-Dec-2022

Summary

Official Symbol
ZNF350provided by HGNC
Official Full Name
zinc finger protein 350provided by HGNC
Primary source
HGNC:HGNC:16656
See related
Ensembl:ENSG00000256683 MIM:605422; AllianceGenome:HGNC:16656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFQR; ZBRK1
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 10.8), thyroid (RPKM 4.3) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF350 in Genome Data Viewer
Location:
19q13.41
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51964340..51986840, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55051534..55074038, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52467593..52490093, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 41 pseudogene Neighboring gene zinc finger protein 613 Neighboring gene ZNF350 antisense RNA 1 Neighboring gene zinc finger protein 615 Neighboring gene uncharacterized LOC124904755 Neighboring gene zinc finger protein 614

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 350
Names
KRAB zinc finger protein ZFQR
zinc finger and BRCA1-interacting protein with a KRAB domain 1
zinc finger protein ZBRK1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021632.4NP_067645.3  zinc finger protein 350

    See identical proteins and their annotated locations for NP_067645.3

    Status: VALIDATED

    Source sequence(s)
    AC011460, AF309561, AU135269, BC009921, BM674621
    Consensus CDS
    CCDS12845.1
    UniProtKB/Swiss-Prot
    Q9GZX5, Q9HAQ4
    Related
    ENSP00000243644.3, ENST00000243644.9
    Conserved Domains (3) summary
    smart00349
    Location:968
    KRAB; krueppel associated box
    COG5048
    Location:160422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51964340..51986840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027094.2XP_016882583.1  zinc finger protein 350 isoform X1

  2. XM_017027098.2XP_016882587.1  zinc finger protein 350 isoform X2

    UniProtKB/Swiss-Prot
    Q9GZX5, Q9HAQ4
    Conserved Domains (3) summary
    smart00349
    Location:968
    KRAB; krueppel associated box
    COG5048
    Location:160422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_047439182.1XP_047295138.1  zinc finger protein 350 isoform X1

  4. XM_017027099.2XP_016882588.1  zinc finger protein 350 isoform X2

    UniProtKB/Swiss-Prot
    Q9GZX5, Q9HAQ4
    Conserved Domains (3) summary
    smart00349
    Location:968
    KRAB; krueppel associated box
    COG5048
    Location:160422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_047439183.1XP_047295139.1  zinc finger protein 350 isoform X1

  6. XM_047439185.1XP_047295141.1  zinc finger protein 350 isoform X2

    UniProtKB/Swiss-Prot
    Q9HAQ4
  7. XM_047439184.1XP_047295140.1  zinc finger protein 350 isoform X2

    UniProtKB/Swiss-Prot
    Q9HAQ4
  8. XM_017027100.1XP_016882589.1  zinc finger protein 350 isoform X2

    UniProtKB/Swiss-Prot
    Q9GZX5, Q9HAQ4
    Conserved Domains (3) summary
    smart00349
    Location:968
    KRAB; krueppel associated box
    COG5048
    Location:160422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_017027096.2XP_016882585.1  zinc finger protein 350 isoform X1

  10. XM_047439187.1XP_047295143.1  zinc finger protein 350 isoform X3

  11. XM_047439186.1XP_047295142.1  zinc finger protein 350 isoform X3

  12. XM_047439188.1XP_047295144.1  zinc finger protein 350 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55051534..55074038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)