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ZNF350 zinc finger protein 350 [ Homo sapiens (human) ]

Gene ID: 59348, updated on 10-Oct-2019

Summary

Official Symbol
ZNF350provided by HGNC
Official Full Name
zinc finger protein 350provided by HGNC
Primary source
HGNC:HGNC:16656
See related
Ensembl:ENSG00000256683 MIM:605422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFQR; ZBRK1
Expression
Ubiquitous expression in prostate (RPKM 10.8), thyroid (RPKM 4.3) and 24 other tissues See more
Orthologs

Genomic context

See ZNF350 in Genome Data Viewer
Location:
19q13.41
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51964340..51986856, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52467593..52490079, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 41 pseudogene Neighboring gene zinc finger protein 613 Neighboring gene ZNF350 antisense RNA 1 Neighboring gene zinc finger protein 615 Neighboring gene zinc finger protein 614 Neighboring gene uncharacterized LOC112268244

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 350
Names
KRAB zinc finger protein ZFQR
zinc finger and BRCA1-interacting protein with a KRAB domain 1
zinc finger protein ZBRK1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021632.4NP_067645.3  zinc finger protein 350

    See identical proteins and their annotated locations for NP_067645.3

    Status: VALIDATED

    Source sequence(s)
    AC011460, AF309561, AU135269, BC009921, BM674621
    Consensus CDS
    CCDS12845.1
    UniProtKB/Swiss-Prot
    Q9GZX5
    Related
    ENSP00000243644.3, ENST00000243644.9
    Conserved Domains (3) summary
    smart00349
    Location:968
    KRAB; krueppel associated box
    COG5048
    Location:160422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51964340..51986856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027094.1XP_016882583.1  zinc finger protein 350 isoform X1

  2. XM_011527196.1XP_011525498.1  zinc finger protein 350 isoform X4

    Conserved Domains (5) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:124386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:200220
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:310332
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212235
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017027098.1XP_016882587.1  zinc finger protein 350 isoform X3

    UniProtKB/Swiss-Prot
    Q9GZX5
    Conserved Domains (3) summary
    smart00349
    Location:968
    KRAB; krueppel associated box
    COG5048
    Location:160422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_017027099.1XP_016882588.1  zinc finger protein 350 isoform X3

    UniProtKB/Swiss-Prot
    Q9GZX5
    Conserved Domains (3) summary
    smart00349
    Location:968
    KRAB; krueppel associated box
    COG5048
    Location:160422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_017027101.1XP_016882590.1  zinc finger protein 350 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:6196
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1030
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_017027102.2XP_016882591.1  zinc finger protein 350 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:6196
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1030
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_017027103.2XP_016882592.1  zinc finger protein 350 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:6196
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1030
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_024451633.1XP_024307401.1  zinc finger protein 350 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:6196
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1030
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_024451634.1XP_024307402.1  zinc finger protein 350 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:6196
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1030
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_017027100.1XP_016882589.1  zinc finger protein 350 isoform X3

    UniProtKB/Swiss-Prot
    Q9GZX5
    Conserved Domains (3) summary
    smart00349
    Location:968
    KRAB; krueppel associated box
    COG5048
    Location:160422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:236256
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_017027096.1XP_016882585.1  zinc finger protein 350 isoform X1

  12. XM_017027095.1XP_016882584.1  zinc finger protein 350 isoform X1

  13. XM_024451635.1XP_024307403.1  zinc finger protein 350 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:6196
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1030
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. XM_024451632.1XP_024307400.1  zinc finger protein 350 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:166428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242262
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:132
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
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