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GNB4 G protein subunit beta 4 [ Homo sapiens (human) ]

Gene ID: 59345, updated on 10-Oct-2024

Summary

Official Symbol
GNB4provided by HGNC
Official Full Name
G protein subunit beta 4provided by HGNC
Primary source
HGNC:HGNC:20731
See related
Ensembl:ENSG00000114450 MIM:610863; AllianceGenome:HGNC:20731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG2B; CMTD1F
Summary
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 14.7), appendix (RPKM 12.1) and 24 other tissues See more
Orthologs
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Genomic context

See GNB4 in Genome Data Viewer
Location:
3q26.33
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (179396088..179527798, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (182199923..182331637, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (179113876..179169258, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14916 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20865 Neighboring gene zinc finger protein 639 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:179065206-179065735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20866 Neighboring gene mitofusin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20867 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:179160994-179161145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14919 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:179178405-179178606 Neighboring gene translation machinery-associated protein 7-like Neighboring gene ribosomal protein L29 pseudogene 34 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 7 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:179244611-179245161 Neighboring gene Sharpr-MPRA regulatory region 7561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14921 Neighboring gene uncharacterized LOC124909462 Neighboring gene actin like 6A Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:179321716-179322582 Neighboring gene mitochondrial ribosomal protein L47

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Charcot-Marie-Tooth disease dominant intermediate F
MedGen: C4749463 OMIM: 615185 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosomal membrane HDA PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit beta-4
Names
G protein beta-4 subunit
guanine nucleotide binding protein (G protein), beta polypeptide 4
heterotrimeric guanine nucleotide-binding protein 2B
transducin beta chain 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033163.1 RefSeqGene

    Range
    5114..60496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021629.4NP_067642.1  guanine nucleotide-binding protein subunit beta-4

    See identical proteins and their annotated locations for NP_067642.1

    Status: REVIEWED

    Source sequence(s)
    AC007620
    Consensus CDS
    CCDS3230.1
    UniProtKB/Swiss-Prot
    B3KMH5, D3DNR8, Q9HAV0
    UniProtKB/TrEMBL
    A8K3F6
    Related
    ENSP00000232564.3, ENST00000232564.8
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    179396088..179527798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448654.1XP_047304610.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    UniProtKB/Swiss-Prot
    B3KMH5, D3DNR8, Q9HAV0
  2. XM_047448653.1XP_047304609.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    UniProtKB/Swiss-Prot
    B3KMH5, D3DNR8, Q9HAV0
  3. XM_006713721.3XP_006713784.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    See identical proteins and their annotated locations for XP_006713784.1

    UniProtKB/Swiss-Prot
    B3KMH5, D3DNR8, Q9HAV0
    UniProtKB/TrEMBL
    A8K3F6
    Related
    ENSP00000501882.1, ENST00000676128.1
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  4. XM_005247692.3XP_005247749.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    See identical proteins and their annotated locations for XP_005247749.1

    UniProtKB/Swiss-Prot
    B3KMH5, D3DNR8, Q9HAV0
    UniProtKB/TrEMBL
    A8K3F6
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    182199923..182331637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347425.1XP_054203400.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    UniProtKB/Swiss-Prot
    B3KMH5, D3DNR8, Q9HAV0
  2. XM_054347424.1XP_054203399.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    UniProtKB/Swiss-Prot
    B3KMH5, D3DNR8, Q9HAV0
  3. XM_054347427.1XP_054203402.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    UniProtKB/Swiss-Prot
    B3KMH5, D3DNR8, Q9HAV0
  4. XM_054347426.1XP_054203401.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    UniProtKB/Swiss-Prot
    B3KMH5, D3DNR8, Q9HAV0