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ALOXE3 arachidonate lipoxygenase 3 [ Homo sapiens (human) ]

Gene ID: 59344, updated on 26-Jul-2021

Summary

Official Symbol
ALOXE3provided by HGNC
Official Full Name
arachidonate lipoxygenase 3provided by HGNC
Primary source
HGNC:HGNC:13743
See related
Ensembl:ENSG00000179148 MIM:607206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARCI3; E-LOX; eLOX3; eLOX-3
Summary
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Expression
Restricted expression toward skin (RPKM 14.1) See more
Orthologs
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Genomic context

See ALOXE3 in Genome Data Viewer
Location:
17p13.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8095900..8118916, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7999218..8022234, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene arachidonate 12-lipoxygenase, 12R type Neighboring gene uncharacterized LOC107985075 Neighboring gene microRNA 4314 Neighboring gene tRNA-Lys (anticodon TTT) 3-5 Neighboring gene tRNA-Gln (anticodon CTG) 1-5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119694, MGC119695, MGC119696

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of skin barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hepoxilin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoxygenase pathway TAS
Traceable Author Statement
more info
 
involved_in peroxisome proliferator activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sphingolipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hydroperoxide isomerase ALOXE3
Names
Epidermal lipoxygenase-3
e-LOX-3
epidermal LOX-3
epidermal lipoxygenase
epidermis-type lipoxygenase 3
hydroperoxy dehydratase ALOXE3
hydroperoxy icosatetraenoate dehydratase
hydroperoxy icosatetraenoate isomerase
NP_001159432.1
NP_001356375.1
NP_067641.2
XP_016880410.1
XP_016880411.1
XP_016880412.1
XP_016880413.1
XP_016880414.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015807.1 RefSeqGene

    Range
    5001..28017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001165960.1NP_001159432.1  hydroperoxide isomerase ALOXE3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001159432.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF182218, AK296416, DC376381
    Consensus CDS
    CCDS54084.1
    UniProtKB/Swiss-Prot
    Q9BYJ1
    Conserved Domains (2) summary
    cd01753
    Location:134248
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:400834
    Lipoxygenase; Lipoxygenase
  2. NM_001369446.1NP_001356375.1  hydroperoxide isomerase ALOXE3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC129492
    Conserved Domains (2) summary
    cd01753
    Location:2116
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:267701
    Lipoxygenase
  3. NM_021628.3NP_067641.2  hydroperoxide isomerase ALOXE3 isoform 2

    See identical proteins and their annotated locations for NP_067641.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AF182218, AK313677, DA183156
    Consensus CDS
    CCDS11130.1
    UniProtKB/Swiss-Prot
    Q9BYJ1
    Related
    ENSP00000400581.2, ENST00000448843.7
    Conserved Domains (2) summary
    cd01753
    Location:2116
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    cl27717
    Location:268702
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8095900..8118916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024922.2XP_016880411.1  hydroperoxide isomerase ALOXE3 isoform X2

  2. XM_017024921.2XP_016880410.1  hydroperoxide isomerase ALOXE3 isoform X1

  3. XM_017024924.2XP_016880413.1  hydroperoxide isomerase ALOXE3 isoform X4

  4. XM_017024923.2XP_016880412.1  hydroperoxide isomerase ALOXE3 isoform X3

  5. XM_017024925.2XP_016880414.1  hydroperoxide isomerase ALOXE3 isoform X4

RNA

  1. XR_001752579.2 RNA Sequence

  2. XR_001752580.2 RNA Sequence

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