Format

Send to:

Choose Destination

SENP2 SUMO specific peptidase 2 [ Homo sapiens (human) ]

Gene ID: 59343, updated on 3-Jan-2019

Summary

Official Symbol
SENP2provided by HGNC
Official Full Name
SUMO specific peptidase 2provided by HGNC
Primary source
HGNC:HGNC:23116
See related
Ensembl:ENSG00000163904 MIM:608261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AXAM2; SMT3IP2
Summary
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
Expression
Broad expression in testis (RPKM 37.1), brain (RPKM 13.4) and 24 other tissues See more
Orthologs

Genomic context

See SENP2 in Genome Data Viewer
Location:
3q27.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (185586243..185631101)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185300284..185348889)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene lipase H Neighboring gene uncharacterized LOC107986055 Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene insulin like growth factor 2 mRNA binding protein 2 Neighboring gene IGF2BP2 antisense RNA 1 Neighboring gene microRNA 548aq

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Nuclear pore complex, organism-specific biosystem (from KEGG)
    Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Nuclear pore complex, conserved biosystem (from KEGG)
    Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Processing and activation of SUMO, organism-specific biosystem (from REACTOME)
    Processing and activation of SUMO, organism-specific biosystemThe initial translation products of SUMO1, SUMO2, and SUMO3 are precursors that have extra amino acid residues at the C-terminus (reviewed in Wang and Dasso 2009, Wilkinson and Henley 2010, Hannoun ...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • SUMO is proteolytically processed, organism-specific biosystem (from REACTOME)
    SUMO is proteolytically processed, organism-specific biosystemSUMO1, 2, and 3 are initially expressed as propeptides containing extra residues at the C-terminus. (SUMO1 has 4 residues, SUMO2 has 2 residues, and SUMO3 has 11 residues,) SENP1, 2, and 5 are endopr...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1331, DKFZp762A2316

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SUMO-specific endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
SUMO-specific endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein desumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein desumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with PML body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sentrin-specific protease 2
Names
SMT3-specific isopeptidase 2
SUMO1/sentrin/SMT3 specific peptidase 2
SUMO1/sentrin/SMT3 specific protease 2
sentrin (SUMO1) specific peptidase 2
sentrin/SUMO-specific protease SENP2
NP_067640.2
XP_005247747.2
XP_005247748.1
XP_016862462.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021627.3NP_067640.2  sentrin-specific protease 2

    See identical proteins and their annotated locations for NP_067640.2

    Status: VALIDATED

    Source sequence(s)
    AC016961, AF151697, AL834380, BC018020, BC040609
    Consensus CDS
    CCDS33902.1
    UniProtKB/Swiss-Prot
    Q9HC62
    Related
    ENSP00000296257.5, ENST00000296257.9
    Conserved Domains (1) summary
    COG5160
    Location:384589
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    185586243..185631101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247690.3XP_005247747.2  sentrin-specific protease 2 isoform X1

    Conserved Domains (1) summary
    cl23802
    Location:370540
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
  2. XM_017006973.2XP_016862462.1  sentrin-specific protease 2 isoform X3

  3. XM_005247691.3XP_005247748.1  sentrin-specific protease 2 isoform X2

    Conserved Domains (1) summary
    cl23802
    Location:221469
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
Support Center