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HRH4 histamine receptor H4 [ Homo sapiens (human) ]

Gene ID: 59340, updated on 23-Nov-2021

Summary

Official Symbol
HRH4provided by HGNC
Official Full Name
histamine receptor H4provided by HGNC
Primary source
HGNC:HGNC:17383
See related
Ensembl:ENSG00000134489 MIM:606792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105
Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See HRH4 in Genome Data Viewer
Location:
18q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (24460637..24479974)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (22040601..22059938)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 1A Neighboring gene microRNA 320c-2 Neighboring gene impact RWD domain protein Neighboring gene uncharacterized LOC105372026 Neighboring gene zinc finger protein 470 pseudogene Neighboring gene eukaryotic translation initiation factor 4A3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133027

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histamine receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
histamine H4 receptor
Names
G-protein coupled receptor 105
SP9144
pfi-013

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143828.2NP_001137300.1  histamine H4 receptor isoform 2

    See identical proteins and their annotated locations for NP_001137300.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, also known as H4R(302), which is shorter than isoform 1.
    Source sequence(s)
    AC007922, AF312230, BC069136, DQ835186
    Consensus CDS
    CCDS45841.1
    UniProtKB/Swiss-Prot
    Q9H3N8
    Related
    ENSP00000402526.2, ENST00000426880.2
    Conserved Domains (1) summary
    pfam00001
    Location:211270
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001160166.2NP_001153638.1  histamine H4 receptor isoform 3

    See identical proteins and their annotated locations for NP_001153638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon resulting in a frameshift, compared to variant 1. The resulting isoform (3), also known as H4R(67), has a substantially shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC007922, AF312230, BC069136, DQ835187
    UniProtKB/Swiss-Prot
    Q9H3N8
    UniProtKB/TrEMBL
    B2KJ49
    Conserved Domains (2) summary
    cd14964
    Location:1842
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:1667
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_021624.4NP_067637.2  histamine H4 receptor isoform 1

    See identical proteins and their annotated locations for NP_067637.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007922, AF312230
    Consensus CDS
    CCDS11887.1
    UniProtKB/Swiss-Prot
    Q9H3N8
    Related
    ENSP00000256906.4, ENST00000256906.5
    Conserved Domains (1) summary
    cd15295
    Location:16374
    7tmA_Histamine_H4R; histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    24460637..24479974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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