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RBL2 RB transcriptional corepressor like 2 [ Homo sapiens (human) ]

Gene ID: 5934, updated on 3-May-2020

Summary

Official Symbol
RBL2provided by HGNC
Official Full Name
RB transcriptional corepressor like 2provided by HGNC
Primary source
HGNC:HGNC:9894
See related
Ensembl:ENSG00000103479 MIM:180203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rb2; P130
Expression
Ubiquitous expression in lymph node (RPKM 41.9), testis (RPKM 38.9) and 25 other tissues See more
Orthologs

Genomic context

See RBL2 in Genome Data Viewer
Location:
16q12.2
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (53434471..53491648)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (53468351..53525560)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene u3 small nucleolar ribonucleoprotein protein MPP10-like Neighboring gene uncharacterized LOC102723373 Neighboring gene RNA, U6 small nuclear 1153, pseudogene Neighboring gene AKT interacting protein Neighboring gene uncharacterized LOC105371268 Neighboring gene uncharacterized LOC105371269

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
Tat tat HIV-1 Tat can inhibit the growth control activity exerted by pRb2/p130 in the T98G cell line, and results show that pRb2/p130 mRNA levels increase in the presence of Tat, whereas no change in the phosphorylation status of pRb2/p130 is observed PubMed
tat HIV-1 Tat protein specifically binds to pRb2/p130 and data suggest this interaction results in the deregulation of the control exerted by pRb2/p130 on the cell cycle, indicating a potential role in AIDS-related oncogenesis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II activating transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
retinoblastoma-like protein 2
Names
130 kDa retinoblastoma-associated protein
PRB2
RBR-2
retinoblastoma-like 2
retinoblastoma-related protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323608.2NP_001310537.1  retinoblastoma-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007342
    Consensus CDS
    CCDS10748.1
    UniProtKB/Swiss-Prot
    Q08999
    Conserved Domains (3) summary
    pfam01857
    Location:8351017
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:417609
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:104236
    DUF3452; Domain of unknown function (DUF3452)
  2. NM_001323609.2NP_001310538.1  retinoblastoma-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007342
  3. NM_001323610.2NP_001310539.1  retinoblastoma-like protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007342
  4. NM_001323611.1NP_001310540.1  retinoblastoma-like protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007342
    Conserved Domains (3) summary
    pfam01857
    Location:761943
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:343535
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:30162
    DUF3452; Domain of unknown function (DUF3452)
  5. NM_005611.4NP_005602.3  retinoblastoma-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_005602.3

    Status: VALIDATED

    Source sequence(s)
    BC034490, X76061
    Consensus CDS
    CCDS10748.1
    UniProtKB/Swiss-Prot
    Q08999
    Related
    ENSP00000262133.6, ENST00000262133.11
    Conserved Domains (3) summary
    pfam01857
    Location:8351017
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:417609
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:104236
    DUF3452; Domain of unknown function (DUF3452)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    53434471..53491648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523253.2XP_011521555.1  retinoblastoma-like protein 2 isoform X1

    Related
    ENST00000379935.8
    Conserved Domains (3) summary
    pfam01857
    Location:619801
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:201393
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:120
    DUF3452; Domain of unknown function (DUF3452)
  2. XM_017023513.1XP_016879002.1  retinoblastoma-like protein 2 isoform X1

    Conserved Domains (3) summary
    pfam01857
    Location:619801
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:201393
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:120
    DUF3452; Domain of unknown function (DUF3452)
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