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Adcy10 adenylate cyclase 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59320, updated on 18-Apr-2019

Summary

Official Symbol
Adcy10provided by RGD
Official Full Name
adenylate cyclase 10provided by RGD
Primary source
RGD:708450
See related
Ensembl:ENSRNOG00000053410
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sac
Summary
cytosolic adenylyl cyclase [RGD, Feb 2006]
Expression
Biased expression in Testes (RPKM 147.9), Liver (RPKM 19.0) and 5 other tissues See more
Orthologs

Genomic context

See Adcy10 in Genome Data Viewer
Location:
13q23
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83701952..83787010)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (88583534..88667840)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene myelin protein zero-like 1 Neighboring gene transfer RNA proline (anticodon AGG)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
bicarbonate binding ISO
Inferred from Sequence Orthology
more info
PubMed 
bicarbonate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cAMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to inorganic substance ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to inorganic substance ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial cilium movement ISO
Inferred from Sequence Orthology
more info
PubMed 
epithelial cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
basal part of cell IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with motile cilium ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
adenylate cyclase type 10
Names
adenylate cyclase 10 (soluble)
germ cell soluble adenylyl cyclase
soluble adenylyl cyclase
testicular soluble adenylyl cyclase
NP_067716.1
XP_008767899.1
XP_008767900.1
XP_008767901.1
XP_008767902.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021684.1NP_067716.1  adenylate cyclase type 10

    See identical proteins and their annotated locations for NP_067716.1

    Status: PROVISIONAL

    Source sequence(s)
    AF081941
    UniProtKB/Swiss-Prot
    Q9Z286
    Conserved Domains (3) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485670
    AAA_16; AAA ATPase domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    83701952..83787010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769677.2XP_008767899.1  adenylate cyclase type 10 isoform X1

    See identical proteins and their annotated locations for XP_008767899.1

    UniProtKB/Swiss-Prot
    Q9Z286
    Conserved Domains (3) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485670
    AAA_16; AAA ATPase domain
  2. XM_008769680.2XP_008767902.1  adenylate cyclase type 10 isoform X2

    Conserved Domains (3) summary
    cd07302
    Location:40235
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:423608
    AAA_16; AAA ATPase domain
  3. XM_008769678.2XP_008767900.1  adenylate cyclase type 10 isoform X1

    See identical proteins and their annotated locations for XP_008767900.1

    UniProtKB/Swiss-Prot
    Q9Z286
    Conserved Domains (3) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485670
    AAA_16; AAA ATPase domain
  4. XM_008769679.2XP_008767901.1  adenylate cyclase type 10 isoform X1

    See identical proteins and their annotated locations for XP_008767901.1

    UniProtKB/Swiss-Prot
    Q9Z286
    Related
    ENSRNOP00000072356.1, ENSRNOT00000082677.1
    Conserved Domains (3) summary
    cd07302
    Location:40214
    CHD; cyclase homology domain
    COG2114
    Location:42197
    AcyC; Adenylate cyclase, class 3 [Signal transduction mechanisms]
    pfam13191
    Location:485670
    AAA_16; AAA ATPase domain

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    77464675..77547216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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