Format

Send to:

Choose Destination

Camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59314, updated on 18-Apr-2019

Summary

Official Symbol
Camk2n2provided by RGD
Official Full Name
calcium/calmodulin-dependent protein kinase II inhibitor 2provided by RGD
Primary source
RGD:708411
See related
Ensembl:ENSRNOG00000038184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
inhibits the activity of Ca2+/calmodulin-dependent protein kinase II (CaM-KII); may play a role in regulation of synaptic plasticity [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 90.4), Testes (RPKM 18.9) and 1 other tissue See more
Orthologs

Genomic context

See Camk2n2 in Genome Data Viewer
Location:
11q23
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (83975430..83976557)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (87047758..87048885)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, non-ATPase 2 Neighboring gene uncharacterized LOC102551589 Neighboring gene endothelin-converting enzyme 2 Neighboring gene EEF1A lysine methyltransferase 4 Neighboring gene ALG3, alpha-1,3- mannosyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium-dependent protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase II inhibitor 2
Names
CaM-KII inhibitory protein
caM-KIIN
caM-KIINbeta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021678.1NP_067710.1  calcium/calmodulin-dependent protein kinase II inhibitor 2

    See identical proteins and their annotated locations for NP_067710.1

    Status: PROVISIONAL

    Source sequence(s)
    AF041854
    UniProtKB/Swiss-Prot
    Q9Z2N6
    Related
    ENSRNOP00000054937.3, ENSRNOT00000058131.4
    Conserved Domains (1) summary
    pfam15170
    Location:179
    CaM-KIIN; Calcium/calmodulin-dependent protein kinase II inhibitor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    83975430..83976557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    79129393..79129646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center