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CACNG7 calcium voltage-gated channel auxiliary subunit gamma 7 [ Homo sapiens (human) ]

Gene ID: 59284, updated on 11-Jun-2021

Summary

Official Symbol
CACNG7provided by HGNC
Official Full Name
calcium voltage-gated channel auxiliary subunit gamma 7provided by HGNC
Primary source
HGNC:HGNC:13626
See related
Ensembl:ENSG00000105605 MIM:606899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]
Expression
Restricted expression toward brain (RPKM 18.0) See more
Orthologs
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Genomic context

See CACNG7 in Genome Data Viewer
Location:
19q13.42
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (53909278..53943950)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54412532..54447204)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MYADM antisense RNA 1 Neighboring gene myeloid associated differentiation marker Neighboring gene protein kinase C gamma Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 8 Neighboring gene microRNA 935 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated calcium channel activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of L-type voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cerebellar mossy fiber IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated calcium channel complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
voltage-dependent calcium channel gamma-7 subunit
Names
TARP gamma-7
calcium channel, voltage-dependent, gamma subunit 7
neuronal voltage-gated calcium channel gamma-7 subunit
transmembrane AMPAR regulatory protein gamma-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384801.1NP_001371730.1  voltage-dependent calcium channel gamma-7 subunit isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC008440
    Conserved Domains (2) summary
    PHA03378
    Location:162291
    PHA03378; EBNA-3B; Provisional
    cl21598
    Location:18143
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  2. NM_031896.5NP_114102.2  voltage-dependent calcium channel gamma-7 subunit isoform 1

    See identical proteins and their annotated locations for NP_114102.2

    Status: REVIEWED

    Source sequence(s)
    AC008440
    Consensus CDS
    CCDS12868.1
    UniProtKB/Swiss-Prot
    P62955
    Related
    ENSP00000375647.1, ENST00000391767.6
    Conserved Domains (1) summary
    cl21598
    Location:16195
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    53909278..53943950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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