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TLNRD1 talin rod domain containing 1 [ Homo sapiens (human) ]

Gene ID: 59274, updated on 13-May-2022

Summary

Official Symbol
TLNRD1provided by HGNC
Official Full Name
talin rod domain containing 1provided by HGNC
Primary source
HGNC:HGNC:13519
See related
Ensembl:ENSG00000140406 MIM:615466; AllianceGenome:HGNC:13519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MESDC1
Summary
This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. [provided by RefSeq, Nov 2016]
Orthologs
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Genomic context

See TLNRD1 in Genome Data Viewer
Location:
15q25.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (81000923..81005788)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (78864568..78869433)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (81293264..81298129)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mesoderm development LRP chaperone Neighboring gene Sharpr-MPRA regulatory region 7880 Neighboring gene microRNA 4514 Neighboring gene Sharpr-MPRA regulatory region 4802 Neighboring gene uncharacterized LOC124903540

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with stress fiber ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
talin rod domain-containing protein 1
Names
mesoderm development candidate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052069.1 RefSeqGene

    Range
    4970..9835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022566.3NP_072088.1  talin rod domain-containing protein 1

    See identical proteins and their annotated locations for NP_072088.1

    Status: REVIEWED

    Source sequence(s)
    AC068870, AY007810, BC084554, CN370100, DN995580
    Consensus CDS
    CCDS10316.1
    UniProtKB/Swiss-Prot
    Q9H1K6
    Related
    ENSP00000267984.2, ENST00000267984.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    81000923..81005788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    78864568..78869433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)