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TLNRD1 talin rod domain containing 1 [ Homo sapiens (human) ]

Gene ID: 59274, updated on 8-Oct-2017
Official Symbol
TLNRD1provided by HGNC
Official Full Name
talin rod domain containing 1provided by HGNC
Primary source
HGNC:HGNC:13519
See related
Ensembl:ENSG00000140406 MIM:615466; Vega:OTTHUMG00000144185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MESDC1
Summary
This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. [provided by RefSeq, Nov 2016]
Orthologs
Location:
15q25.1
Exon count:
1
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (81000954..81004004)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (81293295..81296345)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene cell migration inducing hyaluronan binding protein Neighboring gene mesoderm development LRP chaperone Neighboring gene microRNA 4514 Neighboring gene uncharacterized LOC107984726 Neighboring gene cilia and flagella associated protein 161 Neighboring gene acidic nuclear phosphoprotein 32 family member B pseudogene 3

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC99595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with stress fiber ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
mesoderm development candidate 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052069.1 RefSeqGene

    Range
    5001..8051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022566.2NP_072088.1  mesoderm development candidate 1

    See identical proteins and their annotated locations for NP_072088.1

    Status: REVIEWED

    Source sequence(s)
    AY007810, BC084554, CN370100, DN995580
    Consensus CDS
    CCDS10316.1
    UniProtKB/Swiss-Prot
    Q9H1K6
    Related
    ENSP00000267984.2, OTTHUMP00000185570, ENST00000267984.3, OTTHUMT00000291390

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

    Range
    81000954..81004004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    81411241..81414291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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