Format

Send to:

Choose Destination

PLAAT4 phospholipase A and acyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 5920, updated on 11-Sep-2019

Summary

Official Symbol
PLAAT4provided by HGNC
Official Full Name
phospholipase A and acyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:9869
See related
Ensembl:ENSG00000133321 MIM:605092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIG1; TIG3; HRSL4; HRASLS4; PLAAT-4; RARRES3; PLA1/2-3
Summary
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
Annotation information
Note: RARRES3 (Gene ID: 5920) and DDX58 (Gene ID: 23586) share the RIG1/RIG-1 alias in common. RIG1 is a widely used alternative name for DExD/H-box helicase 58 (DDX58), which can be confused with the retinoic acid receptor responder 3 (RARRES3) gene, since they share the same alias. [22 Jan 2019]
Expression
Ubiquitous expression in small intestine (RPKM 43.2), duodenum (RPKM 36.6) and 24 other tissues See more
Orthologs

Genomic context

See PLAAT4 in Genome Data Viewer
Location:
11q12.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (63536808..63546458)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63304273..63313930)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TMSB4X pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 8142 Neighboring gene phospholipase A and acyltransferase 2 Neighboring gene uncharacterized LOC105369335 Neighboring gene phospholipase A and acyltransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Acyl chain remodelling of PE, organism-specific biosystem (from REACTOME)
    Acyl chain remodelling of PE, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylethanolamine (PE) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid ...
  • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
    Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8906

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phospholipase A and acyltransferase 4
Names
HRAS-like suppressor 4
RAR-responsive protein TIG3
phospholipase A/acyltransferase-4
retinoic acid receptor responder (tazarotene induced) 3
retinoic acid receptor responder 3
retinoic acid receptor responder protein 3
retinoic acid-inducible gene 1
retinoid-inducible gene 1 protein
tazarotene-induced gene 3 protein
NP_004576.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004585.5NP_004576.2  phospholipase A and acyltransferase 4

    See identical proteins and their annotated locations for NP_004576.2

    Status: VALIDATED

    Source sequence(s)
    BC009678, DA973023, KF455398
    Consensus CDS
    CCDS41662.1
    UniProtKB/Swiss-Prot
    Q9UL19
    Related
    ENSP00000255688.3, ENST00000255688.8
    Conserved Domains (1) summary
    pfam04970
    Location:20125
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    63536808..63546458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center