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RARRES1 retinoic acid receptor responder 1 [ Homo sapiens (human) ]

Gene ID: 5918, updated on 12-Oct-2019

Summary

Official Symbol
RARRES1provided by HGNC
Official Full Name
retinoic acid receptor responder 1provided by HGNC
Primary source
HGNC:HGNC:9867
See related
Ensembl:ENSG00000118849 MIM:605090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LXNL; TIG1; PERG-1
Summary
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 33.7), urinary bladder (RPKM 25.5) and 17 other tissues See more
Orthologs

Genomic context

See RARRES1 in Genome Data Viewer
Location:
3q25.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (158696892..158732944, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (158414892..158450642, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene methylthioadenosine phosphorylase pseudogene 1 Neighboring gene G elongation factor mitochondrial 1 Neighboring gene latexin Neighboring gene uncharacterized LOC112268457 Neighboring gene cytokine receptor CRL2 Neighboring gene VISTA enhancer hs1990 Neighboring gene ribosomal protein L35a pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retinoic acid receptor responder protein 1
Names
RAR-responsive protein TIG1
latexin-like
phorbol ester-induced gene 1 protein
retinoic acid receptor responder (tazarotene induced) 1
tazarotene-induced gene 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002888.3NP_002879.2  retinoic acid receptor responder protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_002879.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' end-region compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC080013, BC029640, BM919188
    Consensus CDS
    CCDS54665.1
    UniProtKB/Swiss-Prot
    P49788
    Related
    ENSP00000418556.1, ENST00000479756.1
    Conserved Domains (1) summary
    pfam06907
    Location:52227
    Latexin; Latexin
  2. NM_206963.2NP_996846.1  retinoic acid receptor responder protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_996846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer isoform (1).
    Source sequence(s)
    AC080013, AK130079, BC029640, BM919188
    Consensus CDS
    CCDS3184.1
    UniProtKB/Swiss-Prot
    P49788
    Related
    ENSP00000237696.5, ENST00000237696.10
    Conserved Domains (1) summary
    pfam06907
    Location:52274
    Latexin; Latexin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    158696892..158732944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247686.5XP_005247743.3  retinoic acid receptor responder protein 1 isoform X1

RNA

  1. XR_001740228.2 RNA Sequence

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