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CG18735 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 59137, updated on 4-Apr-2024

Summary

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Official Symbol
CG18735provided by FlyBase
Primary source
FLYBASE:FBgn0042098
Locus tag
Dmel_CG18735
See related
AllianceGenome:FB:FBgn0042098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG18735; SP22
Summary
Enables serine hydrolase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to several human genes including HPN (hepsin); PRSS33 (serine protease 33); and TPSAB1 (tryptase alpha/beta 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CG18735 in Genome Data Viewer
Location:
58A1-58A1; 2-97 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21798017..21799195, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17685522..17686700, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lysyl oxidase-like 2 Neighboring gene uncharacterized protein Neighboring gene tracheal-prostasin Neighboring gene long non-coding RNA:CR9284

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Gene Expression Program for the Formation of Wing Cuticle in Drosophila. Sobala LF, et al. PLoS Genet, 2016 May. PMID 27232182, Free PMC Article
  2. Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. Díaz-Castillo C, et al. Mol Biol Evol, 2012 Sep. PMID 22427708
  3. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400
  4. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721
  5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG18735-PA
NP_652645.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21798017..21799195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_144388.2 → NP_652645.1  uncharacterized protein Dmel_CG18735 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652645.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7V4
    Related
    FBpp0071658
    Conserved Domains (2) summary
    smart00020
    Location:82 → 311
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:83 → 314
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I7V4 Q9I7V4

Gene LinkOut

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