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Tgfb1 transforming growth factor, beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 59086, updated on 21-May-2019

Summary

Official Symbol
Tgfb1provided by RGD
Official Full Name
transforming growth factor, beta 1provided by RGD
Primary source
RGD:69051
See related
Ensembl:ENSRNOG00000020652
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tgfb
Summary
binds the TGFbeta receptor; plays a role in regulation of cell growth and proliferation; induces synthesis of extracellular matrix proteins and may play a role in fibrosis [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 118.3), Thymus (RPKM 42.1) and 6 other tissues See more
Orthologs

Genomic context

See Tgfb1 in Genome Data Viewer
Location:
1q21
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (82480875..82497196)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (83742151..83758472)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene transmembrane protein 91 Neighboring gene B9 domain containing 2 Neighboring gene coiled-coil domain containing 97 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, organism-specific biosystem (from WikiPathways)
    Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
    Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Chronic myeloid leukemia, conserved biosystem (from KEGG)
    Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokines and Inflammatory Response (BioCarta), organism-specific biosystem (from WikiPathways)
    Cytokines and Inflammatory Response (BioCarta), organism-specific biosystemSee BioCarta version: http://www.biocarta.com/pathfiles/h_inflamPathway.asp
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Downregulation of TGF-beta receptor signaling, organism-specific biosystem (from REACTOME)
    Downregulation of TGF-beta receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Elastic fibre formation, organism-specific biosystem (from REACTOME)
    Elastic fibre formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
    Endochondral Ossification, organism-specific biosystem
    Endochondral Ossification
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Genetic alterations of lung cancer, organism-specific biosystem (from WikiPathways)
    Genetic alterations of lung cancer, organism-specific biosystemExpression patterns of two major tumor suppressor pathways in lung cancer. These pathways are functionally linked to lung cancer and play role as a component of checkpoints and growth inhibitory path...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
    Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
    Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
  • Leishmaniasis, organism-specific biosystem (from KEGG)
    Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Leishmaniasis, conserved biosystem (from KEGG)
    Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Molecules associated with elastic fibres, organism-specific biosystem (from REACTOME)
    Molecules associated with elastic fibres, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-integrin membrane-ECM interactions, organism-specific biosystem (from REACTOME)
    Non-integrin membrane-ECM interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Pancreatic cancer, organism-specific biosystem (from KEGG)
    Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pancreatic cancer, conserved biosystem (from KEGG)
    Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Renal cell carcinoma, organism-specific biosystem (from KEGG)
    Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
  • Renal cell carcinoma, conserved biosystem (from KEGG)
    Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
    Signaling by TGF-beta Receptor Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...
  • Syndecan interactions, organism-specific biosystem (from REACTOME)
    Syndecan interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
  • TGF-beta receptor signaling activates SMADs, organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling activates SMADs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystem (from REACTOME)
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF-beta signaling, organism-specific biosystem (from KEGG)
    TGF-beta signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • TGF-beta signaling, conserved biosystem (from KEGG)
    TGF-beta signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • Th17 cell differentiation, organism-specific biosystem (from KEGG)
    Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Th17 cell differentiation, conserved biosystem (from KEGG)
    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
antigen binding ISO
Inferred from Sequence Orthology
more info
PubMed 
antigen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein N-terminus binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
transforming growth factor beta receptor binding TAS
Traceable Author Statement
more info
PubMed 
type I transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
type I transforming growth factor beta receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
type II transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type II transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
type II transforming growth factor beta receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
type III transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
type III transforming growth factor beta receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
ATP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
SMAD protein complex assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
SMAD protein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell activation ISO
Inferred from Sequence Orthology
more info
PubMed 
T cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
T cell homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains IEA
Inferred from Electronic Annotation
more info
 
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains ISO
Inferred from Sequence Orthology
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
animal organ regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
aortic valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
branch elongation involved in mammary gland duct branching IEA
Inferred from Electronic Annotation
more info
 
branch elongation involved in mammary gland duct branching ISO
Inferred from Sequence Orthology
more info
PubMed 
cell activation ISO
Inferred from Sequence Orthology
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
PubMed 
cell cycle arrest ISS
Inferred from Sequence or Structural Similarity
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell junction organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to insulin-like growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to ionizing radiation IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to organic cyclic compound ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to transforming growth factor beta stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
common-partner SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
common-partner SMAD protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
connective tissue development ISO
Inferred from Sequence Orthology
more info
PubMed 
defense response to fungus, incompatible interaction IDA
Inferred from Direct Assay
more info
PubMed 
digestive tract development IEP
Inferred from Expression Pattern
more info
PubMed 
embryonic liver development IEA
Inferred from Electronic Annotation
more info
 
embryonic liver development ISO
Inferred from Sequence Orthology
more info
PubMed 
endoderm development IEA
Inferred from Electronic Annotation
more info
 
endoderm development ISO
Inferred from Sequence Orthology
more info
PubMed 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
epidermal growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
PubMed 
evasion or tolerance of host defenses by virus ISO
Inferred from Sequence Orthology
more info
PubMed 
evasion or tolerance of host defenses by virus ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular matrix assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
extrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
face morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
frontal suture morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
germ cell migration IEA
Inferred from Electronic Annotation
more info
 
germ cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
PubMed 
heart valve morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
hematopoietic progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
hyaluronan catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
inner ear development IEP
Inferred from Expression Pattern
more info
PubMed 
lens fiber cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lens fiber cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
lipopolysaccharide-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
lung development TAS
Traceable Author Statement
more info
PubMed 
lymph node development IEA
Inferred from Electronic Annotation
more info
 
lymph node development ISO
Inferred from Sequence Orthology
more info
PubMed 
mammary gland branching involved in thelarche IEA
Inferred from Electronic Annotation
more info
 
mammary gland branching involved in thelarche ISO
Inferred from Sequence Orthology
more info
PubMed 
mammary gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane protein intracellular domain proteolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane protein intracellular domain proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle checkpoint ISO
Inferred from Sequence Orthology
more info
PubMed 
mitotic cell cycle checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
mononuclear cell proliferation IEA
Inferred from Electronic Annotation
more info
 
mononuclear cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
morphogenesis of a branching structure IDA
Inferred from Direct Assay
more info
PubMed 
muscle cell cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of biomineral tissue development ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of blood vessel endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytolysis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytolysis ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of hyaluronan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-17 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of macrophage cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of skeletal muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neural tube closure ISO
Inferred from Sequence Orthology
more info
PubMed 
neural tube development ISO
Inferred from Sequence Orthology
more info
PubMed 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
PubMed 
ossification involved in bone remodeling ISO
Inferred from Sequence Orthology
more info
PubMed 
ossification involved in bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
pathway-restricted SMAD protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphate-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphate-containing compound metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of NAD+ ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of SMAD protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of blood vessel endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cellular protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of collagen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of exit from mitosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of histone acetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone deacetylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of interleukin-17 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of isotype switching to IgA isotypes ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of isotype switching to IgA isotypes ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microglia differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of microglia differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mononuclear cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of odontogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of odontogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of production of miRNAs involved in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein complex assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein import into nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of receptor clustering IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor clustering ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of regulatory T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of smooth muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of superoxide anion generation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
PubMed 
protein export from nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
receptor catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
receptor catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of SMAD protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of binding ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of branching involved in mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cartilage development IEA
Inferred from Electronic Annotation
more info
 
regulation of cartilage development ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
NOT regulation of epithelial to mesenchymal transition involved in endocardial cushion formation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of interleukin-23 production IEA
Inferred from Electronic Annotation
more info
 
regulation of interleukin-23 production ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulatory T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
response to cholesterol ISO
Inferred from Sequence Orthology
more info
PubMed 
response to cholesterol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol ISO
Inferred from Sequence Orthology
more info
PubMed 
response to estradiol ISS
Inferred from Sequence or Structural Similarity
more info
 
response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to laminar fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
response to progesterone ISO
Inferred from Sequence Orthology
more info
PubMed 
response to progesterone ISS
Inferred from Sequence or Structural Similarity
more info
 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to salt IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding ISO
Inferred from Sequence Orthology
more info
PubMed 
response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
salivary gland morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
tolerance induction to self antigen IEA
Inferred from Electronic Annotation
more info
 
tolerance induction to self antigen ISO
Inferred from Sequence Orthology
more info
PubMed 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
transforming growth factor beta receptor signaling pathway involved in heart development IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway involved in heart development ISO
Inferred from Sequence Orthology
more info
PubMed 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
PubMed 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
ventricular cardiac muscle tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
blood microparticle ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with microvillus ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with microvillus ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transforming growth factor beta-1 proprotein
Names
TGF-beta-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021578.2NP_067589.1  transforming growth factor beta-1 proprotein precursor

    See identical proteins and their annotated locations for NP_067589.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076380
    UniProtKB/Swiss-Prot
    P17246
    Related
    ENSRNOP00000028051.2, ENSRNOT00000028051.4
    Conserved Domains (2) summary
    smart00204
    Location:293390
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:29261
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    82480875..82497196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    75636001..75652315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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