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ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 [ Homo sapiens (human) ]

Gene ID: 59084, updated on 1-Jun-2020

Summary

Official Symbol
ENPP5provided by HGNC
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase family member 5provided by HGNC
Primary source
HGNC:HGNC:13717
See related
Ensembl:ENSG00000112796 MIM:617001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPP5; NPP-5
Summary
This gene encodes a type-I transmembrane glycoprotein. Studies in rat suggest the encoded protein may play a role in neuronal cell communications. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2014]
Expression
Biased expression in thyroid (RPKM 24.6), testis (RPKM 20.9) and 13 other tissues See more
Orthologs

Genomic context

See ENPP5 in Genome Data Viewer
Location:
6p21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (46159182..46171010, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (46126922..46138737, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel 5 Neighboring gene RNA, U6 small nuclear 754, pseudogene Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 4 Neighboring gene uncharacterized LOC105375079 Neighboring gene actin gamma 1 pseudogene 9 Neighboring gene regulator of calcineurin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0879

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell communication IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 5
Names
E-NPP 5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033986.1 RefSeqGene

    Range
    5001..16829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290072.2NP_001277001.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001277001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY358514, BC027615, BF593433, BX647968, DC321540
    Consensus CDS
    CCDS4915.1
    UniProtKB/Swiss-Prot
    Q9UJA9
    Related
    ENSP00000360436.1, ENST00000371383.7
    Conserved Domains (1) summary
    pfam01663
    Location:30342
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  2. NM_001290073.1NP_001277002.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK295192, BC027615, BF593433, BX647968, DC332590
    UniProtKB/Swiss-Prot
    Q9UJA9
    UniProtKB/TrEMBL
    B4DHN2
    Conserved Domains (2) summary
    pfam01663
    Location:1248
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:1288
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
  3. NM_021572.5NP_067547.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC027615, BF593433, BX647968, DC332590
    Consensus CDS
    CCDS4915.1
    UniProtKB/Swiss-Prot
    Q9UJA9
    Related
    ENSP00000230565.3, ENST00000230565.3
    Conserved Domains (1) summary
    pfam01663
    Location:30342
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    46159182..46171010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514786.3XP_011513088.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform X1

    See identical proteins and their annotated locations for XP_011513088.1

    UniProtKB/Swiss-Prot
    Q9UJA9
    Conserved Domains (1) summary
    pfam01663
    Location:30342
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
  2. XM_005249260.4XP_005249317.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform X1

    See identical proteins and their annotated locations for XP_005249317.1

    UniProtKB/Swiss-Prot
    Q9UJA9
    Conserved Domains (1) summary
    pfam01663
    Location:30342
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
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