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CARD18 caspase recruitment domain family member 18 [ Homo sapiens (human) ]

Gene ID: 59082, updated on 24-Nov-2020

Summary

Official Symbol
CARD18provided by HGNC
Official Full Name
caspase recruitment domain family member 18provided by HGNC
Primary source
HGNC:HGNC:28861
See related
Ensembl:ENSG00000255501 MIM:605354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICEBERG; UNQ5804; pseudo-ICE
Expression
Biased expression in skin (RPKM 6.9) and esophagus (RPKM 0.8) See more
Orthologs

Genomic context

See CARD18 in Genome Data Viewer
Location:
11q22.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (105137714..105139769, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (105008448..105010461, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family member 17 Neighboring gene caspase 1 pseudogene 3 Neighboring gene caspase 1 pseudogene 1 Neighboring gene uncharacterized LOC105369469 Neighboring gene olfactory receptor family 2 subfamily AL member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CARD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
caspase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
caspase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
inhibition of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caspase recruitment domain-containing protein 18
Names
ICEBERG caspase-1 inhibitor
caspase-1 inhibitor Iceberg

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021571.4NP_067546.1  caspase recruitment domain-containing protein 18

    See identical proteins and their annotated locations for NP_067546.1

    Status: VALIDATED

    Source sequence(s)
    AP003181, AW295205, AY358231
    Consensus CDS
    CCDS53705.1
    UniProtKB/Swiss-Prot
    P57730
    Related
    ENSP00000436691.1, ENST00000530950.2
    Conserved Domains (1) summary
    cd08325
    Location:687
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    105137714..105139769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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