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RAP1B RAP1B, member of RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5908, updated on 1-Jun-2020

Summary

Official Symbol
RAP1Bprovided by HGNC
Official Full Name
RAP1B, member of RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9857
See related
Ensembl:ENSG00000127314 MIM:179530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K-REV; RAL1B
Summary
This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in lymph node (RPKM 83.8), appendix (RPKM 79.8) and 25 other tissues See more
Orthologs

Genomic context

See RAP1B in Genome Data Viewer
Location:
12q15
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (68610899..68671901)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (69004619..69054385)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 3-like Neighboring gene ribosomal protein SA pseudogene 12 Neighboring gene ribosomal protein L10 pseudogene 12 Neighboring gene small nucleolar RNA, H/ACA box 70G Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 4 Neighboring gene uncharacterized LOC100507250 Neighboring gene ribosomal protein L7 pseudogene 42 Neighboring gene nucleoporin 107 Neighboring gene keratin 8 pseudogene 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RAP1B, member of RAS oncogene family (RAP1B) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18601, DKFZp586H0723

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Rap protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rap protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular response to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to gonadotropin-releasing hormone IEA
Inferred from Electronic Annotation
more info
 
establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
NOT microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of integrin activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to carbohydrate IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
NOT membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rap-1b
Names
GTP-binding protein smg p21B
RAS-related protein RAP1B
Ras family small GTP binding protein RAP1B
small GTP binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010942.3NP_001010942.1  ras-related protein Rap-1b isoform 1 precursor

    See identical proteins and their annotated locations for NP_001010942.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB062128, AC015550, AC090061, CX868584, DB448914
    Consensus CDS
    CCDS8984.1
    UniProtKB/Swiss-Prot
    P61224
    UniProtKB/TrEMBL
    A0A024RB87
    Related
    ENSP00000250559.9, ENST00000250559.14
    Conserved Domains (1) summary
    cd04175
    Location:3167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms
  2. NM_001251917.2NP_001238846.1  ras-related protein Rap-1b isoform 2

    See identical proteins and their annotated locations for NP_001238846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC015550, AC090061, AJ420497, AK301401, CX868584, DB448914
    Consensus CDS
    CCDS58254.1
    UniProtKB/Swiss-Prot
    P61224
    Related
    ENSP00000444830.1, ENST00000539091.5
    Conserved Domains (1) summary
    cl21455
    Location:3125
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_001251918.2NP_001238847.1  ras-related protein Rap-1b isoform 2

    See identical proteins and their annotated locations for NP_001238847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1. Variants 3 and 4 encode the same isoform (2).
    Source sequence(s)
    AC015550, AC090061, AJ420497, AK316447, CX868584, DB448914
    Consensus CDS
    CCDS58254.1
    UniProtKB/Swiss-Prot
    P61224
    UniProtKB/TrEMBL
    B7ZAY2
    Related
    ENSP00000399986.2, ENST00000450214.6
    Conserved Domains (1) summary
    cl21455
    Location:3125
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001251921.2NP_001238850.1  ras-related protein Rap-1b isoform 3

    See identical proteins and their annotated locations for NP_001238850.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC015550, AC090061, AJ420497, AK298818, CX868584, DB448914
    Consensus CDS
    CCDS58253.1
    UniProtKB/Swiss-Prot
    P61224
    Related
    ENSP00000446318.1, ENST00000540209.5
    Conserved Domains (1) summary
    cl21455
    Location:3148
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. NM_001251922.2NP_001238851.1  ras-related protein Rap-1b isoform 4

    See identical proteins and their annotated locations for NP_001238851.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC015550, AC090061, AJ420497, AK301428, CX868584, DB448914
    Consensus CDS
    CCDS58252.1
    UniProtKB/Swiss-Prot
    P61224
    Related
    ENSP00000440014.1, ENST00000542145.5
    Conserved Domains (1) summary
    cl27030
    Location:2121
    Ras; Ras family
  6. NM_015646.6NP_056461.1  ras-related protein Rap-1b isoform 1 precursor

    See identical proteins and their annotated locations for NP_056461.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC015550, AC090061, BC000176, CX868584, DB448914
    Consensus CDS
    CCDS8984.1
    UniProtKB/Swiss-Prot
    P61224
    UniProtKB/TrEMBL
    A0A024RB87
    Related
    ENSP00000377085.5, ENST00000393436.9
    Conserved Domains (1) summary
    cd04175
    Location:3167
    Rap1; Rap1 family GTPase consists of Rap1a and Rap1b isoforms

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    68610899..68671901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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