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Mettl9 methyltransferase like 9 [ Mus musculus (house mouse) ]

Gene ID: 59052, updated on 7-Apr-2025

Summary

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Official Symbol
Mettl9provided by MGI
Official Full Name
methyltransferase like 9provided by MGI
Primary source
MGI:MGI:1914862
See related
Ensembl:ENSMUSG00000030876 AllianceGenome:MGI:1914862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drev; mMETTL9; MNCb-5680; 0610012D09Rik
Summary
Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in mitochondrion. Predicted to be active in endoplasmic reticulum. Is expressed in retina inner nuclear layer and retina outer nuclear layer. Orthologous to human METTL9 (methyltransferase 9, His-X-His N1(pi)-histidine). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 36.9), CNS E14 (RPKM 28.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mettl9 in Genome Data Viewer
Location:
7 F2; 7 65.07 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120631717..120676058)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (121032384..121076835)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 13B Neighboring gene STARR-positive B cell enhancer ABC_E4973 Neighboring gene predicted pseudogene 9234 Neighboring gene predicted gene, 25924 Neighboring gene predicted gene, 27991 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene immunoglobulin superfamily, member 6 Neighboring gene otoancorin Neighboring gene STARR-seq mESC enhancer starr_20059 Neighboring gene src family associated phosphoprotein 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. Lv M, et al. Protein Cell, 2021 Dec. PMID 34218407, Free PMC Article
  2. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Davydova E, et al. Nat Commun, 2021 Feb 9. PMID 33563959, Free PMC Article
  3. Characterization of the human PAP1 gene and its homologue possible involvement in mouse embryonic development. Shu KX, et al. Colloids Surf B Biointerfaces, 2006 Sep 1. PMID 16837177
  4. siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9. Daitoku H, et al. J Biol Chem, 2021 Nov. PMID 34562450, Free PMC Article
  5. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. Bates EE, et al. Immunogenetics, 2000 Nov. PMID 11132146

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. siRNA screening identifies METTL9 as a histidine Npi-methyltransferase that targets the proinflammatory protein S100A9.
    Title: siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9.
  2. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
    Title: The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-L-histidine N-pros-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-L-histidine N-pros-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein-L-histidine N-pros-methyltransferase
Names
DORA reverse strand protein
methyltransferase-like protein 9
NP_001405493.1
NP_001405494.1
NP_001405495.1
NP_001405496.1
NP_001405497.1
NP_001405498.1
NP_001405499.1
NP_001405500.1
NP_001405501.1
NP_001405502.1
NP_001405503.1
NP_001405504.1
NP_001405505.1
NP_001405506.1
NP_001405507.1
NP_001405508.1
NP_001405509.1
NP_001405510.1
NP_001405511.1
NP_001405512.1
NP_067529.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418564.1 → NP_001405493.1  protein-L-histidine N-pros-methyltransferase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC140782

  2. NM_001418565.1 → NP_001405494.1  protein-L-histidine N-pros-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140782

  3. NM_001418566.1 → NP_001405495.1  protein-L-histidine N-pros-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC140782

  4. NM_001418567.1 → NP_001405496.1  protein-L-histidine N-pros-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC140782
    UniProtKB/TrEMBL
    A0A140LJ45

  5. NM_001418568.1 → NP_001405497.1  protein-L-histidine N-pros-methyltransferase isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC140782

  6. NM_001418569.1 → NP_001405498.1  protein-L-histidine N-pros-methyltransferase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC140782

  7. NM_001418570.1 → NP_001405499.1  protein-L-histidine N-pros-methyltransferase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC140782

  8. NM_001418571.1 → NP_001405500.1  protein-L-histidine N-pros-methyltransferase isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC140782
    UniProtKB/TrEMBL
    A0A140LJ45

  9. NM_001418572.1 → NP_001405501.1  protein-L-histidine N-pros-methyltransferase isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC140782

  10. NM_001418573.1 → NP_001405502.1  protein-L-histidine N-pros-methyltransferase isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC140782

  11. NM_001418574.1 → NP_001405503.1  protein-L-histidine N-pros-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC140782
    UniProtKB/TrEMBL
    A0A140LJ45

  12. NM_001418575.1 → NP_001405504.1  protein-L-histidine N-pros-methyltransferase isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC140782
    UniProtKB/TrEMBL
    A0A140LJ45

  13. NM_001418576.1 → NP_001405505.1  protein-L-histidine N-pros-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC140782
    UniProtKB/TrEMBL
    A0A140LJ45
    Related
    ENSMUSP00000147071.2, ENSMUST00000207351.2

  14. NM_001418577.1 → NP_001405506.1  protein-L-histidine N-pros-methyltransferase isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC140782
    UniProtKB/TrEMBL
    A0A140LJ45

  15. NM_001418578.1 → NP_001405507.1  protein-L-histidine N-pros-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC140782
    UniProtKB/TrEMBL
    A0A140LJ45

  16. NM_001418579.1 → NP_001405508.1  protein-L-histidine N-pros-methyltransferase isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC140782
    UniProtKB/TrEMBL
    A0A140LJ45

  17. NM_001418580.1 → NP_001405509.1  protein-L-histidine N-pros-methyltransferase isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC140782

  18. NM_001418581.1 → NP_001405510.1  protein-L-histidine N-pros-methyltransferase isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC140782

  19. NM_001418582.1 → NP_001405511.1  protein-L-histidine N-pros-methyltransferase isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC140782

  20. NM_001418583.1 → NP_001405512.1  protein-L-histidine N-pros-methyltransferase isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC140782

  21. NM_021554.3 → NP_067529.2  protein-L-histidine N-pros-methyltransferase isoform 1 precursor

    See identical proteins and their annotated locations for NP_067529.2

    Status: VALIDATED

    Source sequence(s)
    AC140782
    Consensus CDS
    CCDS21800.1
    UniProtKB/Swiss-Prot
    A0JG25, Q3TDX0, Q641L4, Q8R567, Q9EPL3, Q9EPL4, Q9JJ88
    Related
    ENSMUSP00000033163.7, ENSMUST00000033163.8
    Conserved Domains (1) summary
    pfam05219
    Location:56 → 317
    DREV; DREV methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    120631717..120676058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPL4.1 GenPept UniProtKB/Swiss-Prot:Q9EPL4

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