Mettl9 methyltransferase like 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl9provided by MGI
Official Full Name: methyltransferase like 9provided by MGI
Primary source: MGI:MGI:1914862
See related: Ensembl:ENSMUSG00000030876 AllianceGenome:MGI:1914862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Drev; mMETTL9; MNCb-5680; 0610012D09Rik
Summary: Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to act upstream of or within methylation. Predicted to be located in mitochondrion. Predicted to be active in endoplasmic reticulum. Is expressed in retina inner nuclear layer and retina outer nuclear layer. Orthologous to human METTL9 (methyltransferase like 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 36.9), CNS E14 (RPKM 28.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 F2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (120631607..120676058)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (121032384..121076835)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

siRNA screening identifies METTL9 as a histidine Npi-methyltransferase that targets the proinflammatory protein S100A9.
Title: siRNA screening identifies METTL9 as a histidine Nπ-methyltransferase that targets the proinflammatory protein S100A9.
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.
Title: The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124470 (e-PCR)
- UniSTS:161292

BE105359 (e-PCR)
- UniSTS:245814

RH134210 (e-PCR)
- UniSTS:217492

D7Mit58 (e-PCR), detects polymorphism
- UniSTS:131282

Homology

Homologs of the Mettl9 gene: The Mettl9 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 502 organisms have orthologs with human gene Mettl9
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-L-histidine N-pros-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-L-histidine N-pros-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein-L-histidine N-pros-methyltransferase; methyltransferase-like protein 9

Names: DORA reverse strand protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418564.1 → NP_001405493.1 protein-L-histidine N-pros-methyltransferase isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418565.1 → NP_001405494.1 protein-L-histidine N-pros-methyltransferase isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418566.1 → NP_001405495.1 protein-L-histidine N-pros-methyltransferase isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418567.1 → NP_001405496.1 protein-L-histidine N-pros-methyltransferase isoform 5

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418568.1 → NP_001405497.1 protein-L-histidine N-pros-methyltransferase isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418569.1 → NP_001405498.1 protein-L-histidine N-pros-methyltransferase isoform 7

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418570.1 → NP_001405499.1 protein-L-histidine N-pros-methyltransferase isoform 8

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418571.1 → NP_001405500.1 protein-L-histidine N-pros-methyltransferase isoform 9

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418572.1 → NP_001405501.1 protein-L-histidine N-pros-methyltransferase isoform 10 precursor

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418573.1 → NP_001405502.1 protein-L-histidine N-pros-methyltransferase isoform 11 precursor

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418574.1 → NP_001405503.1 protein-L-histidine N-pros-methyltransferase isoform 5

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418575.1 → NP_001405504.1 protein-L-histidine N-pros-methyltransferase isoform 9

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418576.1 → NP_001405505.1 protein-L-histidine N-pros-methyltransferase isoform 5

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418577.1 → NP_001405506.1 protein-L-histidine N-pros-methyltransferase isoform 9

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418578.1 → NP_001405507.1 protein-L-histidine N-pros-methyltransferase isoform 5

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418579.1 → NP_001405508.1 protein-L-histidine N-pros-methyltransferase isoform 9

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418580.1 → NP_001405509.1 protein-L-histidine N-pros-methyltransferase isoform 12

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418581.1 → NP_001405510.1 protein-L-histidine N-pros-methyltransferase isoform 13

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418582.1 → NP_001405511.1 protein-L-histidine N-pros-methyltransferase isoform 14

Status: VALIDATED

Source sequence(s)

AC140782
NM_001418583.1 → NP_001405512.1 protein-L-histidine N-pros-methyltransferase isoform 15

Status: VALIDATED

Source sequence(s)

AC140782
NM_021554.3 → NP_067529.2 protein-L-histidine N-pros-methyltransferase isoform 1 precursor

See identical proteins and their annotated locations for NP_067529.2

Status: VALIDATED

Source sequence(s)

AC140782

Consensus CDS

CCDS21800.1

UniProtKB/Swiss-Prot

Q9EPL4, Q9JJ88

Related

ENSMUSP00000033163.7, ENSMUST00000033163.8

Conserved Domains (1) summary

pfam05219
Location:56 → 317

DREV; DREV methyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

120631607..120676058

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242850.1 → XP_030098710.1 methyltransferase-like protein 9 isoform X3

Conserved Domains (1) summary

pfam05219
Location:16 → 276

DREV; DREV methyltransferase
XM_006508093.4 → XP_006508156.1 methyltransferase-like protein 9 isoform X2

Conserved Domains (1) summary

pfam05219
Location:16 → 277

DREV; DREV methyltransferase
XM_006508092.5 → XP_006508155.1 methyltransferase-like protein 9 isoform X1

Conserved Domains (1) summary

pfam05219
Location:56 → 316

DREV; DREV methyltransferase
XM_006508096.4 → XP_006508159.1 methyltransferase-like protein 9 isoform X4

Conserved Domains (1) summary

cl17173
Location:1 → 192

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_030242851.1 → XP_030098711.1 methyltransferase-like protein 9 isoform X5

Conserved Domains (1) summary

cl17173
Location:1 → 191

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...