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RANGAP1 Ran GTPase activating protein 1 [ Homo sapiens (human) ]

Gene ID: 5905, updated on 12-Aug-2018
Official Symbol
RANGAP1provided by HGNC
Official Full Name
Ran GTPase activating protein 1provided by HGNC
Primary source
HGNC:HGNC:9854
See related
Ensembl:ENSG00000100401 MIM:602362; Vega:OTTHUMG00000150940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SD; Fug1; RANGAP
Summary
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in testis (RPKM 19.7), skin (RPKM 13.7) and 25 other tissues See more
Orthologs
See RANGAP1 in Genome Data Viewer
Location:
22q13.2
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (41244777..41302213, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41640781..41682255, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506544 Neighboring gene L3MBTL2, polycomb repressive complex 1 subunit Neighboring gene chondroadherin like Neighboring gene microRNA 6889 Neighboring gene zinc finger CCCH-type containing 7B Neighboring gene uncharacterized LOC100996598 Neighboring gene uncharacterized LOC105373042 Neighboring gene RNA, U6 small nuclear 495, pseudogene Neighboring gene TEF, PAR bZIP transcription factor

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, Ran GTPase activating protein 1 (RANGAP1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Tat tat Interaction of HIV-1 Tat with RANGAP1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed

Go to the HIV-1, Human Interaction Database

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • HIV Infection, organism-specific biosystem (from REACTOME)
    HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
  • HIV Life Cycle, organism-specific biosystem (from REACTOME)
    HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
  • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
    Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
  • Infectious disease, organism-specific biosystem (from REACTOME)
    Infectious disease, organism-specific biosystem
    Infectious disease
  • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
    Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
  • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
    Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Nuclear pore complex, organism-specific biosystem (from KEGG)
    Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Nuclear pore complex, conserved biosystem (from KEGG)
    Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Rev-mediated nuclear export of HIV RNA, organism-specific biosystem (from REACTOME)
    Rev-mediated nuclear export of HIV RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
  • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
    SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
  • SUMOylation of DNA replication proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of DNA replication proteins, organism-specific biosystemThe sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-str...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
  • Signaling events mediated by HDAC Class II, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class II, organism-specific biosystem
    Signaling events mediated by HDAC Class II
  • Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
    Sumoylation by RanBP2 regulates transcriptional repression, organism-specific biosystem
    Sumoylation by RanBP2 regulates transcriptional repression
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1835, MGC20266

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Ran GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to vasopressin IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
aggresome IDA
Inferred from Direct Assay
more info
 
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic periphery of the nuclear pore complex IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear pore TAS
Traceable Author Statement
more info
PubMed 
nuclear pore cytoplasmic filaments IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ran GTPase-activating protein 1
Names
segregation distorter homolog
segregation distortion

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278651.1NP_001265580.1  ran GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_001265580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC004990, BC048990, CX872993, HY062550, HY251691
    Consensus CDS
    CCDS14012.1
    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0, Q9BSK3
    Related
    ENSP00000385866.1, OTTHUMP00000198757, ENST00000405486.5, OTTHUMT00000320605
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  2. NM_001317930.1NP_001304859.1  ran GTPase-activating protein 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC004990, BC041396, HY062550, HY251691
    Consensus CDS
    CCDS14012.1
    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0, Q9BSK3
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  3. NM_002883.3NP_002874.1  ran GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_002874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC004990, BC014044, DA269460, HY062550, HY251691
    Consensus CDS
    CCDS14012.1
    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0, Q9BSK3
    Related
    ENSP00000348577.3, OTTHUMP00000198755, ENST00000356244.7, OTTHUMT00000320603
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    41244777..41302213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028898.2XP_016884387.1  ran GTPase-activating protein 1 isoform X5

  2. XM_017028893.2XP_016884382.1  ran GTPase-activating protein 1 isoform X4

    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  3. XM_017028894.2XP_016884383.1  ran GTPase-activating protein 1 isoform X4

    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  4. XM_011530294.3XP_011528596.1  ran GTPase-activating protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011528596.1

    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  5. XM_017028895.2XP_016884384.1  ran GTPase-activating protein 1 isoform X4

    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  6. XM_006724289.4XP_006724352.1  ran GTPase-activating protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006724352.1

    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  7. XM_017028899.1XP_016884388.1  ran GTPase-activating protein 1 isoform X6

  8. XM_017028896.2XP_016884385.1  ran GTPase-activating protein 1 isoform X4

    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  9. XM_011530293.1XP_011528595.1  ran GTPase-activating protein 1 isoform X3

    Conserved Domains (3) summary
    cd00116
    Location:76368
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:106136
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:416595
    RanGAP1_C; RanGAP1 C-terminal domain
  10. XM_005261695.1XP_005261752.1  ran GTPase-activating protein 1 isoform X1

    Conserved Domains (3) summary
    cd00116
    Location:76413
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:106136
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:461640
    RanGAP1_C; RanGAP1 C-terminal domain
  11. XM_017028897.1XP_016884386.1  ran GTPase-activating protein 1 isoform X4

    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  12. XM_011530295.2XP_011528597.1  ran GTPase-activating protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011528597.1

    UniProtKB/Swiss-Prot
    P46060
    UniProtKB/TrEMBL
    A0A024R1U0
    Related
    ENSP00000401470.2, OTTHUMP00000198758, ENST00000455915.6, OTTHUMT00000320606
    Conserved Domains (3) summary
    cd00116
    Location:21358
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5181
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:409585
    RanGAP1_C; RanGAP1 C-terminal domain
  13. XM_005261696.1XP_005261753.1  ran GTPase-activating protein 1 isoform X2

    Conserved Domains (3) summary
    cd00116
    Location:62399
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:92122
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07834
    Location:447626
    RanGAP1_C; RanGAP1 C-terminal domain
  14. XM_011530297.1XP_011528599.1  ran GTPase-activating protein 1 isoform X7

    Conserved Domains (2) summary
    cd00116
    Location:76416
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:106136
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. XR_002958711.1 RNA Sequence

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