Stard3 START domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stard3provided by MGI
Official Full Name: START domain containing 3provided by MGI
Primary source: MGI:MGI:1929618
See related: Ensembl:ENSMUSG00000018167 AllianceGenome:MGI:1929618
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: es64; Mln64
Summary: Predicted to enable cholesterol binding activity and protein homodimerization activity. Acts upstream of or within progesterone biosynthetic process. Located in endosome and mitochondrion. Is expressed in nervous system. Orthologous to human STARD3 (StAR related lipid transfer domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 38.5), colon adult (RPKM 38.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 D

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98249193..98271938)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98358367..98381112)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of STARD3 attenuates oxidized LDL-induced oxidative stress and inflammation in retinal pigment epithelial cells.
Title: Overexpression of STARD3 attenuates oxidized LDL-induced oxidative stress and inflammation in retinal pigment epithelial cells.
The results suggested that MLN64 played a critical role in the meditation of osteoclastic differentiation, and its suppression alleviated diabetic osteoporosis in streptozotocin-induced mice.
Title: MLN64 deletion suppresses RANKL-induced osteoclastic differentiation and attenuates diabetic osteoporosis in streptozotocin (STZ)-induced mice.
Stard3 is an essential factor for the 3T3-L1 cells' differentiation
Title: Knocking down Stard3 decreases adipogenesis with decreased mitochondrial ROS in 3T3-L1 cells.
The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 (StarD3/MLN64), in BRIN-BD11 insulinoma cells.
Title: The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 (StarD3/MLN64), in BRIN-BD11 insulinoma cells.
a transport pathway for endosomal cholesterol to mitochondria that requires MLN64, but not NPC1
Title: MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein.
Hepatic MLN64 over-expression induced damage and apoptosis in murine livers and altered cholesterol metabolism.
Title: Overexpression of the cholesterol-binding protein MLN64 induces liver damage in the mouse.
mice homozygous for the Mln64 mutant were viable, neurologically intact,and fertile. No significant changes in plasma lipids, liver lipids, or expression of genes involved in sterol metabolism were observed, except for an increase in sterol ester storage
Title: Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Stard3 gene: The Stard3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 489 organisms have orthologs with human gene Stard3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within progesterone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle tethering to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in vesicle tethering to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
colocalizes_with endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
colocalizes_with endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum-endosome membrane contact site	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endoplasmic reticulum-endosome membrane contact site	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	TAS Traceable Author Statement more info	PubMed
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in organelle membrane contact site	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stAR-related lipid transfer protein 3

Names: START domain-containing protein 3; protein ES 64; protein MLN 64; steroidogenic acute regulatory protein related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021547.3 → NP_067522.1 stAR-related lipid transfer protein 3

See identical proteins and their annotated locations for NP_067522.1

Status: VALIDATED

Source sequence(s)

BC058727, BY030024, X82457

Consensus CDS

CCDS25345.1

UniProtKB/Swiss-Prot

Q61542

UniProtKB/TrEMBL

Q544C3

Related

ENSMUSP00000018311.5, ENSMUST00000018311.5

Conserved Domains (2) summary

cd08906
Location:234 → 442

START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins

pfam10457
Location:48 → 213

MENTAL; Cholesterol-capturing domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

98249193..98271938

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533894.1 → XP_006533957.1 stAR-related lipid transfer protein 3 isoform X1

See identical proteins and their annotated locations for XP_006533957.1

Conserved Domains (2) summary

cd08906
Location:255 → 463

START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins

pfam10457
Location:48 → 234

MENTAL; Cholesterol-capturing domain
XM_006533897.3 → XP_006533960.1 stAR-related lipid transfer protein 3 isoform X3

Conserved Domains (2) summary

cd08906
Location:186 → 394

START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins

pfam10457
Location:26 → 165

MENTAL; Cholesterol-capturing domain
XM_006533895.5 → XP_006533958.1 stAR-related lipid transfer protein 3 isoform X1

See identical proteins and their annotated locations for XP_006533958.1

Conserved Domains (2) summary

cd08906
Location:255 → 463

START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins

pfam10457
Location:48 → 234

MENTAL; Cholesterol-capturing domain
XM_006533896.5 → XP_006533959.1 stAR-related lipid transfer protein 3 isoform X2

See identical proteins and their annotated locations for XP_006533959.1

UniProtKB/Swiss-Prot

Q61542

UniProtKB/TrEMBL

Q544C3

Conserved Domains (2) summary

cd08906
Location:234 → 442

START_STARD3-like; Cholesterol-binding START domain of mammalian STARD3 and related proteins

pfam10457
Location:48 → 213

MENTAL; Cholesterol-capturing domain