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Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [ Mus musculus (house mouse) ]

Gene ID: 59029, updated on 8-Feb-2024

Summary

Official Symbol
Psmd14provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14provided by MGI
Primary source
MGI:MGI:1913284
See related
Ensembl:ENSMUSG00000026914 AllianceGenome:MGI:1913284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pad1; Poh1; rpm11; 2610312C03Rik; 3200001M20Rik
Summary
Predicted to enable endopeptidase activator activity; peptidase activity; and proteasome binding activity. Predicted to be involved in double-strand break repair; proteolysis; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within DNA repair and proteolysis. Part of proteasome accessory complex. Is expressed in genitourinary system. Orthologous to human PSMD14 (proteasome 26S subunit, non-ATPase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 35.4), liver E14 (RPKM 33.6) and 25 other tissues See more
Orthologs
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Genomic context

See Psmd14 in Genome Data Viewer
Location:
2 C1.3; 2 35.56 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (61542038..61630720)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (61711694..61800376)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33841 Neighboring gene STARR-seq mESC enhancer starr_04631 Neighboring gene STARR-positive B cell enhancer ABC_E808 Neighboring gene STARR-positive B cell enhancer ABC_E5924 Neighboring gene STARR-positive B cell enhancer ABC_E506 Neighboring gene STARR-positive B cell enhancer ABC_E7821 Neighboring gene TRAF family member-associated Nf-kappa B activator Neighboring gene STARR-positive B cell enhancer mm9_chr2:61481154-61481454 Neighboring gene STARR-seq mESC enhancer starr_04632 Neighboring gene STARR-positive B cell enhancer ABC_E4457 Neighboring gene T-box brain transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_04635 Neighboring gene predicted gene, 39837

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal-dependent deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal-dependent deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of cytosolic proteasome complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome regulatory particle, lid subcomplex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
26S proteasome non-ATPase regulatory subunit 14
Names
26S proteasome non-ATPase subunit
26S proteasome regulatory subunit rpn11
26S proteasome-associated pad1 homolog
MAD1
proteasome 26S subunit, non-ATPase 14
NP_067501.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021526.2NP_067501.2  26S proteasome non-ATPase regulatory subunit 14

    See identical proteins and their annotated locations for NP_067501.2

    Status: VALIDATED

    Source sequence(s)
    AI448878, AK012013, BY324928
    Consensus CDS
    CCDS38127.1
    UniProtKB/Swiss-Prot
    O35593, Q3UB50, Q9CZY6
    UniProtKB/TrEMBL
    Q3UD26
    Related
    ENSMUSP00000028278.8, ENSMUST00000028278.14
    Conserved Domains (1) summary
    cd08069
    Location:21286
    MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    61542038..61630720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)