Nampt nicotinamide phosphoribosyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Namptprovided by MGI
Official Full Name: nicotinamide phosphoribosyltransferaseprovided by MGI
Primary source: MGI:MGI:1929865
See related: Ensembl:ENSMUSG00000020572 AllianceGenome:MGI:1929865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pbef; Pbef1; Visfatin; NAmPRTase; 1110035O14Rik
Summary: Enables identical protein binding activity and nicotinamide phosphoribosyltransferase activity. Involved in circadian regulation of gene expression; nicotinamide metabolic process; and nicotinamide nucleotide biosynthetic process. Acts upstream of or within NAD biosynthetic process. Located in cytoplasm. Is active in cytosol and mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in heart adult (RPKM 19.2), bladder adult (RPKM 15.4) and 28 other tissues See more
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Location:: 12 A3; 12 13.74 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (32870334..32903368)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (32820335..32853369)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nicotinamide phosphoribosyl transferase in mammary gland epithelial cells is required for nicotinamide mononucleotide production in mouse milk.
Title: Nicotinamide phosphoribosyl transferase in mammary gland epithelial cells is required for nicotinamide mononucleotide production in mouse milk.
Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice.
Title: Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice.
Adipocyte-specific inactivation of NAMPT, a key NAD[+] biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging.
Title: Adipocyte-specific inactivation of NAMPT, a key NAD(+) biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging.
Possible involvement of NAMPT in neuronal survival in cerebral ischemic injury under high-glucose conditions through the FoxO3a/LC3 pathway.
Title: Possible involvement of NAMPT in neuronal survival in cerebral ischemic injury under high-glucose conditions through the FoxO3a/LC3 pathway.
NAMPT-Driven M2 Polarization of Tumor-Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer.
Title: NAMPT-Driven M2 Polarization of Tumor-Associated Macrophages Leads to an Immunosuppressive Microenvironment in Colorectal Cancer.
Nicotinamide phosphoribose transferase facilitates macrophage-mediated pulmonary fibrosis through the Sirt1-Smad7 pathway in mice.
Title: Nicotinamide phosphoribose transferase facilitates macrophage-mediated pulmonary fibrosis through the Sirt1-Smad7 pathway in mice.
Nicotine rebalances NAD[+] homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity.
Title: Nicotine rebalances NAD(+) homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity.
The Depletion of NAMPT Disturbs Mitochondrial Homeostasis and Causes Neuronal Degeneration in Mouse Hippocampus.
Title: The Depletion of NAMPT Disturbs Mitochondrial Homeostasis and Causes Neuronal Degeneration in Mouse Hippocampus.
NAMPT is a metabolic checkpoint of IFNgamma-producing CD4[+] T cells in lupus nephritis.
Title: NAMPT is a metabolic checkpoint of IFNγ-producing CD4(+) T cells in lupus nephritis.
Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy.
Title: Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (131)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (3) 1 citation
Targeted (6) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AI480535 (e-PCR)
- UniSTS:180383

AI314458 (e-PCR)
- UniSTS:160198

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nicotinamide phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinamide phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables nicotinamide phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinamide phosphoribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD+ biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within NAD+ biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NAD+ biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in NAD+ biosynthetic process via the salvage pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in NAD+ biosynthetic process via the salvage pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NADP+ biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NADP+ biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of lung blood pressure	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: nicotinamide phosphoribosyltransferase

Names: pre-B-cell colony-enhancing factor 1 homolog

NP_067499.2

EC 2.4.2.12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021524.2 → NP_067499.2 nicotinamide phosphoribosyltransferase

See identical proteins and their annotated locations for NP_067499.2

Status: VALIDATED

Source sequence(s)

AK086415, BY068469, CT572998, CV561474

Consensus CDS

CCDS25871.1

UniProtKB/Swiss-Prot

Q8C3B5, Q99KQ4, Q9JKM0

UniProtKB/TrEMBL

Q3TLX1

Related

ENSMUSP00000020886.8, ENSMUST00000020886.9

Conserved Domains (1) summary

cd01569
Location:12 → 428

PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...