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Huwe1 HECT, UBA and WWE domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 59026, updated on 9-Mar-2023

Summary

Official Symbol
Huwe1provided by MGI
Official Full Name
HECT, UBA and WWE domain containing 1provided by MGI
Primary source
MGI:MGI:1926884
See related
Ensembl:ENSMUSG00000025261 AllianceGenome:MGI:1926884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mule; Ib772; LASU1; Ureb1; Gm1718; Arf-bp1; 5430439H10Rik; C430014N20Rik
Summary
Predicted to enable DNA binding activity and ubiquitin protein ligase activity. Involved in circadian regulation of gene expression and positive regulation of protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in Golgi membrane and nucleus. Is expressed in several structures, including extraembryonic component. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 24.1), CNS E14 (RPKM 22.4) and 28 other tissues See more
Orthologs
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Genomic context

See Huwe1 in Genome Data Viewer
Location:
X; X F3
Exon count:
89
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (150583779..150718413)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (151800785..151935417)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene nuclear encoded rRNA 5S 13 Neighboring gene tubulin tyrosine ligase-like 1 pseudogene Neighboring gene microRNA 3113 Neighboring gene microRNA let7f-2 Neighboring gene microRNA 98 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene hydroxysteroid (17-beta) dehydrogenase 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in histone ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitophagy in response to mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase HUWE1
Names
E3Histone
HECT, UBA and WWE domain-containing protein 1
HECT-type E3 ubiquitin transferase HUWE1
Mcl-1 ubiquitin ligase
URE-B1
URE-binding protein 1
upstream regulatory element binding protein 1
NP_067498.4
XP_006528996.1
XP_006528997.1
XP_006528999.1
XP_006529000.1
XP_006529001.1
XP_006529002.1
XP_006529003.1
XP_006529006.1
XP_006529011.1
XP_006529012.1
XP_006529014.1
XP_011246154.1
XP_030107294.1
XP_030107295.1
XP_030107296.1
XP_030107297.1
XP_030107298.1
XP_030107299.1
XP_030107300.1
XP_030107302.1
XP_030107304.1
XP_030107306.1
XP_030107307.1
XP_030107308.1
XP_030107309.1
XP_030107310.1
XP_030107311.1
XP_030107312.1
XP_030107314.1
XP_030107315.1
XP_030107316.1
XP_030107317.1
XP_030107318.1
XP_036017951.1
XP_036017952.1
XP_036017953.1
XP_036017954.1
XP_036017955.1
XP_036017956.1
XP_036017957.1
XP_036017958.1
XP_036017959.1
XP_036017960.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021523.5NP_067498.4  E3 ubiquitin-protein ligase HUWE1

    See identical proteins and their annotated locations for NP_067498.4

    Status: VALIDATED

    Source sequence(s)
    AL672180, AL954855, BX571795
    Consensus CDS
    CCDS41176.1
    UniProtKB/Swiss-Prot
    Q7TMY8
    UniProtKB/TrEMBL
    A2AFQ0, Q3TNP1, Q4JG03
    Related
    ENSMUSP00000026292.9, ENSMUST00000026292.15
    Conserved Domains (7) summary
    cd00078
    Location:40234376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13171356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16171678
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30113042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27312914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    150583779..150718413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162059.1XP_036017952.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  2. XM_030251448.1XP_030107308.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  3. XM_030251434.1XP_030107294.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  4. XM_030251447.1XP_030107307.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

    Conserved Domains (6) summary
    cd00078
    Location:40864439
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893122
    DUF4414; Domain of unknown function (DUF4414)
  5. XM_036162060.1XP_036017953.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

    Conserved Domains (7) summary
    cd00078
    Location:40684421
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30563087
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27762959
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  6. XM_030251458.1XP_030107318.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

    Conserved Domains (6) summary
    cd00078
    Location:39674320
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:29552988
    DUF4414; Domain of unknown function (DUF4414)
  7. XM_030251444.1XP_030107304.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

    Conserved Domains (6) summary
    cd00078
    Location:40994452
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30873120
    DUF4414; Domain of unknown function (DUF4414)
  8. XM_030251446.1XP_030107306.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

    Conserved Domains (6) summary
    cd00078
    Location:40924445
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13861425
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16861747
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:430892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30803113
    DUF4414; Domain of unknown function (DUF4414)
  9. XM_030251457.1XP_030107317.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

    Conserved Domains (7) summary
    cd00078
    Location:40144367
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13081347
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16081669
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30023033
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27222905
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  10. XM_030251435.1XP_030107295.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  11. XM_006528934.3XP_006528997.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006528997.1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  12. XM_036162063.1XP_036017956.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  13. XM_006528938.3XP_006529001.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529001.1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  14. XM_030251449.1XP_030107309.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  15. XM_006528939.3XP_006529002.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529002.1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  16. XM_006528936.3XP_006528999.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006528999.1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  17. XM_036162061.1XP_036017954.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  18. XM_030251436.1XP_030107296.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  19. XM_036162062.1XP_036017955.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  20. XM_006528937.3XP_006529000.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529000.1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  21. XM_030251455.1XP_030107315.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    UniProtKB/TrEMBL
    A2AFQ0
    Conserved Domains (7) summary
    cd00078
    Location:40234376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13171356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16171678
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30113042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27312914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  22. XM_036162064.1XP_036017957.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  23. XM_006528940.3XP_006529003.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529003.1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  24. XM_036162066.1XP_036017959.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    UniProtKB/TrEMBL
    A2AFQ0
    Conserved Domains (7) summary
    cd00078
    Location:40234376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13171356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16171678
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30113042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27312914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  25. XM_006528948.3XP_006529011.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  26. XM_006528951.3XP_006529014.1  E3 ubiquitin-protein ligase HUWE1 isoform X10

    Conserved Domains (6) summary
    cd00078
    Location:39494302
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:12431282
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:15431604
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:356740
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:29372970
    DUF4414; Domain of unknown function (DUF4414)
  27. XM_006528933.3XP_006528996.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006528996.1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  28. XM_006528949.4XP_006529012.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    See identical proteins and their annotated locations for XP_006529012.1

    UniProtKB/TrEMBL
    A2AFQ0
    Conserved Domains (7) summary
    cd00078
    Location:40234376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13171356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16171678
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30113042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27312914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  29. XM_030251450.1XP_030107310.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  30. XM_011247852.2XP_011246154.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_011246154.1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  31. XM_030251451.1XP_030107311.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  32. XM_030251437.1XP_030107297.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  33. XM_030251452.1XP_030107312.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  34. XM_006528943.3XP_006529006.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    See identical proteins and their annotated locations for XP_006529006.1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  35. XM_030251456.1XP_030107316.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

    UniProtKB/TrEMBL
    A2AFQ0
    Conserved Domains (7) summary
    cd00078
    Location:40234376
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13171356
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16171678
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30113042
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27312914
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  36. XM_036162067.1XP_036017960.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

    Conserved Domains (7) summary
    cd00078
    Location:40144367
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13081347
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16081669
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431814
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30023033
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27222905
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  37. XM_030251454.1XP_030107314.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  38. XM_030251442.2XP_030107302.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  39. XM_030251439.1XP_030107299.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  40. XM_036162065.1XP_036017958.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

    Conserved Domains (7) summary
    cd00078
    Location:40274380
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13211360
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16211682
    WWE; WWE domain
    pfam06012
    Location:18293
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:357818
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30153046
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:27352918
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  41. XM_030251438.1XP_030107298.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  42. XM_030251440.1XP_030107300.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
  43. XM_036162058.1XP_036017951.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

    Conserved Domains (7) summary
    cd00078
    Location:41014454
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14288
    Location:13951434
    UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
    pfam02825
    Location:16951756
    WWE; WWE domain
    pfam06012
    Location:92367
    DUF908; Domain of Unknown Function (DUF908)
    pfam06025
    Location:431892
    DUF913; Domain of Unknown Function (DUF913)
    pfam14377
    Location:30893120
    DUF4414; Domain of unknown function (DUF4414)
    NF033913
    Location:28092992
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA