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RANBP1 RAN binding protein 1 [ Homo sapiens (human) ]

Gene ID: 5902, updated on 9-Feb-2020

Summary

Official Symbol
RANBP1provided by HGNC
Official Full Name
RAN binding protein 1provided by HGNC
Primary source
HGNC:HGNC:9847
See related
Ensembl:ENSG00000099901 MIM:601180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTF9A
Summary
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in testis (RPKM 15.4), lymph node (RPKM 10.2) and 25 other tissues See more
Orthologs

Genomic context

See RANBP1 in Genome Data Viewer
Location:
22q11.21
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20116104..20127355)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20103461..20114880)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene microRNA 1306 Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene microRNA 6816 Neighboring gene small nucleolar RNA, H/ACA box 77B Neighboring gene zinc finger DHHC-type palmitoyltransferase 8 Neighboring gene coiled-coil domain containing 188

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RAN binding protein 1 (RANBP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev RanBP1 competes with Rev for the same nuclear export pathway and as a result can affect Rev-mediated nuclear export of HIV-1 mRNA PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with RAN binding protein 1 (RANBP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37091, FLJ54173, MGC88701

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP-dissociation inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ran GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic centrosome separation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ran-specific GTPase-activating protein
Names
HpaII tiny fragments locus 9A
testis secretory sperm-binding protein Li 221n

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278639.2NP_001265568.1  ran-specific GTPase-activating protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AW404614, CA489474, DC397929, HY229989, X83617
    Consensus CDS
    CCDS74823.1
    UniProtKB/Swiss-Prot
    P43487
    UniProtKB/TrEMBL
    F6WQW2
    Related
    ENSP00000401564.2, ENST00000430524.6
    Conserved Domains (1) summary
    cd13179
    Location:101237
    RanBD_RanBP1; Ran-binding domain
  2. NM_001278640.2NP_001265569.1  ran-specific GTPase-activating protein isoform 3

    See identical proteins and their annotated locations for NP_001265569.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains multiple differences, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AW404614, D38076, HY229989
    Consensus CDS
    CCDS63408.1
    UniProtKB/Swiss-Prot
    P43487
    Related
    ENSP00000384925.1, ENST00000402752.5
    Conserved Domains (1) summary
    cd13179
    Location:24160
    RanBD_RanBP1; Ran-binding domain
  3. NM_001278641.2NP_001265570.1  ran-specific GTPase-activating protein isoform 4

    See identical proteins and their annotated locations for NP_001265570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains multiple differences, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC006547, AW404614, BG717186, BI916757, HY229989
    Related
    ENSP00000413502.2, ENST00000418705.2
    Conserved Domains (1) summary
    cd13179
    Location:1110
    RanBD_RanBP1; Ran-binding domain
  4. NM_002882.4NP_002873.1  ran-specific GTPase-activating protein isoform 2

    See identical proteins and their annotated locations for NP_002873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AW404614, DB459798, HY229989, X83617
    Consensus CDS
    CCDS13775.1
    UniProtKB/Swiss-Prot
    P43487
    UniProtKB/TrEMBL
    A0A140VK94
    Related
    ENSP00000327583.3, ENST00000331821.7
    Conserved Domains (1) summary
    cd13179
    Location:24160
    RanBD_RanBP1; Ran-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20116104..20127355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530290.2XP_011528592.1  ran-specific GTPase-activating protein isoform X4

    See identical proteins and their annotated locations for XP_011528592.1

    UniProtKB/TrEMBL
    B3KUP2
    Conserved Domains (1) summary
    cl17171
    Location:1470
    PH-like; Pleckstrin homology-like domain
  2. XM_017028890.2XP_016884379.1  ran-specific GTPase-activating protein isoform X1

    Conserved Domains (1) summary
    cd13179
    Location:24160
    RanBD_RanBP1; Ran-binding domain
  3. XM_011530289.3XP_011528591.1  ran-specific GTPase-activating protein isoform X3

    See identical proteins and their annotated locations for XP_011528591.1

    UniProtKB/TrEMBL
    B4DE76
    Conserved Domains (1) summary
    cd13179
    Location:24146
    RanBD_RanBP1; Ran-binding domain
  4. XM_011530291.3XP_011528593.1  ran-specific GTPase-activating protein isoform X5

    See identical proteins and their annotated locations for XP_011528593.1

    UniProtKB/TrEMBL
    D3DX26
    Conserved Domains (1) summary
    cd13179
    Location:1110
    RanBD_RanBP1; Ran-binding domain
  5. XM_017028892.1XP_016884381.1  ran-specific GTPase-activating protein isoform X6

    Conserved Domains (1) summary
    cd13179
    Location:1110
    RanBD_RanBP1; Ran-binding domain
  6. XM_017028891.1XP_016884380.1  ran-specific GTPase-activating protein isoform X2

    Related
    ENSP00000404298.1, ENST00000423859.5
    Conserved Domains (1) summary
    cd13179
    Location:1110
    RanBD_RanBP1; Ran-binding domain
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