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Sqor sulfide quinone oxidoreductase [ Mus musculus (house mouse) ]

Gene ID: 59010, updated on 26-Feb-2024

Summary

Official Symbol
Sqorprovided by MGI
Official Full Name
sulfide quinone oxidoreductaseprovided by MGI
Primary source
MGI:MGI:1929899
See related
Ensembl:ENSMUSG00000005803 AllianceGenome:MGI:1929899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sqrdl; 0610039J17Rik; 4930557M22Rik
Summary
Predicted to enable FAD binding activity and sulfide:quinone oxidoreductase activity. Predicted to be involved in hydrogen sulfide metabolic process and sulfide oxidation, using sulfide:quinone oxidoreductase. Located in mitochondrial inner membrane. Orthologous to human SQOR (sulfide quinone oxidoreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 67.7), colon adult (RPKM 56.3) and 14 other tissues See more
Orthologs
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Genomic context

See Sqor in Genome Data Viewer
Location:
2 E5; 2 60.67 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122607249..122651473)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122765327..122809553)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05562 Neighboring gene STARR-positive B cell enhancer ABC_E10136 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 6, pallidin, opposite strand Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 6, pallidin Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:122615227-122615418 Neighboring gene STARR-seq mESC enhancer starr_05563 Neighboring gene predicted gene, 34430 Neighboring gene STARR-seq mESC enhancer starr_05564 Neighboring gene predicted gene, 54147

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
sulfide:quinone oxidoreductase, mitochondrial
Names
flavo-binding protein
sulfide quinone reductase-like
NP_001155975.1
NP_067482.4
XP_006500029.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162503.1NP_001155975.1  sulfide:quinone oxidoreductase, mitochondrial

    See identical proteins and their annotated locations for NP_001155975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075598, BP772838
    Consensus CDS
    CCDS16669.1
    UniProtKB/Swiss-Prot
    Q8BW20, Q91XA1, Q9D891, Q9R112
    UniProtKB/TrEMBL
    Q3UDS4
    Related
    ENSMUSP00000005953.5, ENSMUST00000005953.11
    Conserved Domains (1) summary
    COG0446
    Location:46397
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
  2. NM_021507.5NP_067482.4  sulfide:quinone oxidoreductase, mitochondrial

    See identical proteins and their annotated locations for NP_067482.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075598, AL928950, BP772838
    Consensus CDS
    CCDS16669.1
    UniProtKB/Swiss-Prot
    Q8BW20, Q91XA1, Q9D891, Q9R112
    UniProtKB/TrEMBL
    Q3UDS4
    Related
    ENSMUSP00000106133.3, ENSMUST00000110506.9
    Conserved Domains (1) summary
    COG0446
    Location:46397
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

RNA

  1. NR_027888.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK075598, AL928950, BP772838

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    122607249..122651473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499966.3XP_006500029.1  sulfide:quinone oxidoreductase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006500029.1

    UniProtKB/Swiss-Prot
    Q8BW20, Q91XA1, Q9D891, Q9R112
    UniProtKB/TrEMBL
    Q3UDS4
    Conserved Domains (1) summary
    COG0446
    Location:46397
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]