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Arhgap23 Rho GTPase activating protein 23 [ Mus musculus (house mouse) ]

Gene ID: 58996, updated on 9-Sep-2018

Summary

Official Symbol
Arhgap23provided by MGI
Official Full Name
Rho GTPase activating protein 23provided by MGI
Primary source
MGI:MGI:3697726
See related
Ensembl:ENSMUSG00000049807 Vega:OTTMUSG00000002673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A330041B18Rik
Expression
Ubiquitous expression in adrenal adult (RPKM 28.9), lung adult (RPKM 24.8) and 28 other tissues See more
Orthologs

Genomic context

See Arhgap23 in Genome Data Viewer
Location:
11; 11 D
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (97404393..97502402)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (97311474..97363714)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 179 Neighboring gene suppressor of cytokine signaling 7 Neighboring gene RIKEN cDNA 4933428G20 gene Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene RIKEN cDNA 2410003L11 gene Neighboring gene predicted gene, 38962

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
signal transduction IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 23
Names
rho-type GTPase-activating protein 23

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021493.2NP_067468.2  rho GTPase-activating protein 23

    See identical proteins and their annotated locations for NP_067468.2

    Status: VALIDATED

    Source sequence(s)
    AK173187, BI739912, BM943900, BQ444174, BU505571, BU708895, CB525670, CJ115457, CX243267
    Consensus CDS
    CCDS36293.1
    UniProtKB/Swiss-Prot
    Q69ZH9
    UniProtKB/TrEMBL
    F8VQ11
    Related
    ENSMUSP00000103227.1, ENSMUST00000107601.7
    Conserved Domains (3) summary
    cd04395
    Location:692887
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:480600
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:479598
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    97404393..97502402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533867.2XP_006533930.1  rho GTPase-activating protein 23 isoform X6

    Conserved Domains (4) summary
    cd00992
    Location:23138
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8851080
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:673793
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:672791
    PH; PH domain
  2. XM_006533865.3XP_006533928.1  rho GTPase-activating protein 23 isoform X4

    Conserved Domains (4) summary
    cd00992
    Location:41156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9031098
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:691811
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:690809
    PH; PH domain
  3. XM_006533866.2XP_006533929.1  rho GTPase-activating protein 23 isoform X5

    UniProtKB/TrEMBL
    B1AQY2
    Related
    ENSMUSP00000112999.1, OTTMUSP00000002485, ENSMUST00000121799.7, OTTMUST00000005237
    Conserved Domains (4) summary
    cd00992
    Location:41156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9031098
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:691811
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:690809
    PH; PH domain
  4. XM_006533868.3XP_006533931.2  rho GTPase-activating protein 23 isoform X7

    See identical proteins and their annotated locations for XP_006533931.2

    Conserved Domains (4) summary
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:591710
    PH; PH domain
  5. XM_006533869.3XP_006533932.2  rho GTPase-activating protein 23 isoform X7

    See identical proteins and their annotated locations for XP_006533932.2

    Conserved Domains (4) summary
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:591710
    PH; PH domain
  6. XM_006533861.3XP_006533924.2  rho GTPase-activating protein 23 isoform X1

    Conserved Domains (4) summary
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:591710
    PH; PH domain
  7. XM_006533862.3XP_006533925.2  rho GTPase-activating protein 23 isoform X2

    Conserved Domains (4) summary
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:591710
    PH; PH domain
  8. XM_006533863.3XP_006533926.2  rho GTPase-activating protein 23 isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:721916
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cl17171
    Location:496629
    PH-like; Pleckstrin homology-like domain
  9. XM_006533871.3XP_006533934.1  rho GTPase-activating protein 23 isoform X8

    Conserved Domains (3) summary
    cd04395
    Location:692887
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:480600
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:479598
    PH; PH domain
  10. XM_006533874.3XP_006533937.1  rho GTPase-activating protein 23 isoform X9

    Conserved Domains (2) summary
    cd04395
    Location:107302
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cl17171
    Location:115
    PH-like; Pleckstrin homology-like domain
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