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RALA RAS like proto-oncogene A [ Homo sapiens (human) ]

Gene ID: 5898, updated on 7-Jun-2020

Summary

Official Symbol
RALAprovided by HGNC
Official Full Name
RAS like proto-oncogene Aprovided by HGNC
Primary source
HGNC:HGNC:9839
See related
Ensembl:ENSG00000006451 MIM:179550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAL
Summary
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 22.0), lung (RPKM 20.7) and 25 other tissues See more
Orthologs

Genomic context

See RALA in Genome Data Viewer
Location:
7p14.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (39622955..39708124)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (39663152..39747723)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene thioredoxin related transmembrane protein 1 pseudogene Neighboring gene YAE1 maturation factor of ABCE1 Neighboring gene uncharacterized LOC107986785 Neighboring gene akirin 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 6412 Neighboring gene long intergenic non-protein coding RNA 265 Neighboring gene RNA, U6 small nuclear 719, pseudogene Neighboring gene capicua transcriptional repressor pseudogene 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of v-ral simian leukemia viral oncogene homolog A (RALA) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC48949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Edg-2 lysophosphatidic acid receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myosin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton reorganization IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
membrane raft localization IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Flemming body IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
colocalizes_with endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Ral-A
Names
RALA Ras like proto-oncogene A
RAS-like protein A
Ras family small GTP binding protein RALA
ras related GTP binding protein A
v-ral simian leukemia viral oncogene homolog A (ras related)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005402.4NP_005393.2  ras-related protein Ral-A precursor

    See identical proteins and their annotated locations for NP_005393.2

    Status: REVIEWED

    Source sequence(s)
    BC039858, DC313757
    Consensus CDS
    CCDS5460.1
    UniProtKB/Swiss-Prot
    P11233
    Related
    ENSP00000005257.2, ENST00000005257.7
    Conserved Domains (1) summary
    cd04139
    Location:15177
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    39622955..39708124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515467.1XP_011513769.1  ras-related protein Ral-A isoform X2

  2. XM_011515466.1XP_011513768.1  ras-related protein Ral-A isoform X1

    See identical proteins and their annotated locations for XP_011513768.1

    UniProtKB/Swiss-Prot
    P11233
    Conserved Domains (1) summary
    cd04139
    Location:15177
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
  3. XM_006715762.3XP_006715825.1  ras-related protein Ral-A isoform X1

    See identical proteins and their annotated locations for XP_006715825.1

    UniProtKB/Swiss-Prot
    P11233
    Conserved Domains (1) summary
    cd04139
    Location:15177
    RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
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