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Gabarap GABA type A receptor-associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 58974, updated on 5-Aug-2018

Summary

Official Symbol
Gabarapprovided by RGD
Official Full Name
GABA type A receptor-associated proteinprovided by RGD
Primary source
RGD:61911
See related
Ensembl:ENSRNOG00000017417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
putative microtubule binding protein [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 1314.7), Testes (RPKM 947.4) and 9 other tissues See more
Orthologs

Genomic context

See Gabarap in Genome Data Viewer
Location:
10q24
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56601288..56604223)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (56346407..56349342)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene PHD finger protein 23 Neighboring gene dishevelled segment polarity protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - other, organism-specific biosystem (from KEGG)
    Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Autophagy - other, conserved biosystem (from KEGG)
    Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • GABAergic synapse, organism-specific biosystem (from KEGG)
    GABAergic synapse, organism-specific biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
  • GABAergic synapse, conserved biosystem (from KEGG)
    GABAergic synapse, conserved biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
  • Macroautophagy, organism-specific biosystem (from REACTOME)
    Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
    TBC/RABGAPs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GABA receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
GABA receptor binding ISO
Inferred from Sequence Orthology
more info
 
beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway via death domain receptors ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
autophagosome ISO
Inferred from Sequence Orthology
more info
 
autophagosome ISS
Inferred from Sequence or Structural Similarity
more info
 
autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome membrane ISO
Inferred from Sequence Orthology
more info
 
axoneme ISO
Inferred from Sequence Orthology
more info
 
axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
sperm midpiece IEA
Inferred from Electronic Annotation
more info
 
sperm midpiece ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-aminobutyric acid receptor-associated protein
Names
GABA(A) receptor-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172036.3NP_742033.1  gamma-aminobutyric acid receptor-associated protein

    See identical proteins and their annotated locations for NP_742033.1

    Status: PROVISIONAL

    Source sequence(s)
    BC058441
    UniProtKB/Swiss-Prot
    P60517
    Related
    ENSRNOP00000023724.3, ENSRNOT00000023724.6
    Conserved Domains (1) summary
    cd01611
    Location:5116
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    56601288..56604223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    53868419..53871353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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