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Klf6 Kruppel-like factor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58954, updated on 12-Aug-2018

Summary

Official Symbol
Klf6provided by RGD
Official Full Name
Kruppel-like factor 6provided by RGD
Primary source
RGD:62389
See related
Ensembl:ENSRNOG00000016885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zf9; CPBP; Copeb; Aa1017
Summary
activates transcription from the collagen alpha (I) promoter in vitro; may play a role in activation of hepatic stellate cells in response to injury [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 235.0), Heart (RPKM 128.3) and 9 other tissues See more
Orthologs

Genomic context

See Klf6 in Genome Data Viewer
Location:
17q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (67887939..67945052, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (69616967..69674031, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene similar to heat shock protein 8 Neighboring gene uncharacterized LOC108348615 Neighboring gene uncharacterized LOC102554523 Neighboring gene uncharacterized LOC102554589

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
cellular response to cycloheximide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to peptide IEP
Inferred from Expression Pattern
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
fibrillar center ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Krueppel-like factor 6
Names
core promoter element binding protein
transcription factor Zf9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031642.4NP_113830.2  Krueppel-like factor 6

    See identical proteins and their annotated locations for NP_113830.2

    Status: VALIDATED

    Source sequence(s)
    AABR07028392
    Related
    ENSRNOP00000070743.1, ENSRNOT00000078532.1
    Conserved Domains (4) summary
    COG5048
    Location:211299
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239258
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:234258
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:280305
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    67887939..67945052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254182.2XP_006254244.1  Krueppel-like factor 6 isoform X1

    See identical proteins and their annotated locations for XP_006254244.1

    UniProtKB/TrEMBL
    G3V880
    Related
    ENSRNOP00000023033.5, ENSRNOT00000023033.6
    Conserved Domains (4) summary
    COG5048
    Location:680775
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:705727
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:703727
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:749771
    zf-H2C2_2; Zinc-finger double domain

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    64125707..64134702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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