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Klf6 Kruppel-like factor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58954, updated on 24-Apr-2022

Summary

Official Symbol
Klf6provided by RGD
Official Full Name
Kruppel-like factor 6provided by RGD
Primary source
RGD:62389
See related
Ensembl:ENSRNOG00000016885 AllianceGenome:RGD:62389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zf9; CPBP; Copeb; Aa1017
Summary
Enables DNA-binding transcription factor activity and double-stranded DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to organonitrogen compound; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human KLF6 (Kruppel like factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 235.0), Heart (RPKM 128.3) and 9 other tissues See more
Orthologs
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Genomic context

See Klf6 in Genome Data Viewer
Location:
17q12.1
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (64539456..64548451, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (67887939..67945052, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 3 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 5 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Krueppel-like factor 6
Names
core promoter element binding protein
transcription factor Zf9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031642.5NP_113830.2  Krueppel-like factor 6

    See identical proteins and their annotated locations for NP_113830.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000294
    Related
    ENSRNOP00000070743.2, ENSRNOT00000078532.2
    Conserved Domains (4) summary
    COG5048
    Location:211299
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239258
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:234258
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:280305
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    64539456..64548451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)