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Cpq carboxypeptidase Q [ Rattus norvegicus (Norway rat) ]

Gene ID: 58952, updated on 23-Jul-2026
Official Symbol
Cpqprovided by RGD
Official Full Name
carboxypeptidase Qprovided by RGD
Primary source
RGD:628610
See related
Ensembl:ENSRNOG00000005931 AllianceGenome:RGD:628610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LAL; Pgcp; lal-1
Summary
Predicted to enable metallodipeptidase activity and protein homodimerization activity. Involved in proteolysis; thyroid hormone generation; and tissue regeneration. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and lysosome. Orthologous to human CPQ (carboxypeptidase Q). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 886.6), Liver (RPKM 660.2) and 8 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Cpq in Genome Data Viewer
Location:
7q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (66148973..66719189)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (64264025..64830867)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479601 Neighboring gene syndecan 2 Neighboring gene translationally-controlled tumor protein pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene TSPY-like 5 Neighboring gene spermatogenesis associated 1, pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin. Suban D, et al. Biochimie, 2012 Mar. PMID 22127294
  2. lal-1: a differentially expressed novel gene during proliferation in liver regeneration and in hepatoma cells. Della Fazia MA, et al. Genes Cells, 2002 Nov. PMID 12390252
  3. Purification and primary structure determination of human lysosomal dipeptidase. Dolenc I, et al. Biol Chem, 2003 Feb. PMID 12675526
  4. Purification, cDNA cloning, and expression of a new human blood plasma glutamate carboxypeptidase homologous to N-acetyl-aspartyl-alpha-glutamate carboxypeptidase/prostate-specific membrane antigen. Gingras R, et al. J Biol Chem, 1999 Apr 23. PMID 10206990
  5. Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Danyukova T, et al. Hum Mol Genet, 2018 May 15. PMID 29514215, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lal-1 is involved in liver regeneration and its expression is finely regulated during proliferative process {Liver Annexin Like-1 (lal-1)
    Title: lal-1: a differentially expressed novel gene during proliferation in liver regeneration and in hepatoma cells.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metallodipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallodipeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptide catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone generation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone generation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tissue regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
carboxypeptidase Q
Names
hematopoietic lineage switch 2 related protein
hls2-rp
liver annexin like-1
liver annexin-like protein 1
plasma glutamate carboxypeptidase
XP_008763639.1
XP_038935736.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001440038.1 → NP_001426967.1  carboxypeptidase Q isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q6IRK9, Q9JLV0, Q9Z1Y1
    UniProtKB/TrEMBL
    A0A8I6AKX5

  2. NM_001440041.1 → NP_001426970.1  carboxypeptidase Q isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AKX5, A0ABK0M1S7

  3. NM_031640.2 → NP_113828.2  carboxypeptidase Q isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q6IRK9, Q9JLV0, Q9Z1Y1
    UniProtKB/TrEMBL
    A0A8I6AKX5
    Related
    ENSRNOP00000008211.4, ENSRNOT00000008211.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    66148973..66719189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765417.4 → XP_008763639.1  

    Conserved Domains (1) summary
    cd03883
    Location:42 → 449
    M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase

  2. XM_039079808.2 → XP_038935736.1  

    Related
    ENSRNOP00000108968.1, ENSRNOT00000159568.1
    Conserved Domains (1) summary
    cd03883
    Location:42 → 435
    M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IRK9.1 GenPept UniProtKB/Swiss-Prot:Q6IRK9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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