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Ptafr platelet-activating factor receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 58949, updated on 6-May-2021

Summary

Official Symbol
Ptafrprovided by RGD
Official Full Name
platelet-activating factor receptorprovided by RGD
Primary source
RGD:61897
See related
Ensembl:ENSRNOG00000013231
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
acts as a receptor to mediate the biological effects of platelet-activating factor [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 63.9), Lung (RPKM 25.3) and 9 other tissues See more
Orthologs
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Genomic context

See Ptafr in Genome Data Viewer
Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144765770..144795057)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150746284..150775675)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene microRNA 3583 Neighboring gene uncharacterized LOC102548282 Neighboring gene EYA transcriptional coactivator and phosphatase 3 Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene XK related 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables lipopolysaccharide immune receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet activating factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables platelet activating factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to gravity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inositol trisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in parturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gastro-intestinal system smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of maternal process involved in parturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neutrophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of voltage-gated chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organophosphorus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to symbiotic bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in transcytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
platelet-activating factor receptor
Names
PAF-R
PAFr

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053321.2NP_445773.1  platelet-activating factor receptor

    See identical proteins and their annotated locations for NP_445773.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072491
    UniProtKB/Swiss-Prot
    P46002
    Related
    ENSRNOP00000017687.3, ENSRNOT00000017687.4
    Conserved Domains (1) summary
    pfam00001
    Location:33292
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    144765770..144795057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239063.4XP_006239125.1  platelet-activating factor receptor isoform X1

    See identical proteins and their annotated locations for XP_006239125.1

    UniProtKB/Swiss-Prot
    P46002
    Conserved Domains (1) summary
    pfam00001
    Location:33292
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_006239064.3XP_006239126.1  platelet-activating factor receptor isoform X1

    See identical proteins and their annotated locations for XP_006239126.1

    UniProtKB/Swiss-Prot
    P46002
    Conserved Domains (1) summary
    pfam00001
    Location:33292
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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