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Dynll1 dynein light chain LC8-type 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58945, updated on 30-Sep-2021

Summary

Official Symbol
Dynll1provided by RGD
Official Full Name
dynein light chain LC8-type 1provided by RGD
Primary source
RGD:619866
See related
EnsemblRapid:ENSRNOG00000011222
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pin; Dlc8; 8kDLC; Dnclc1
Summary
inhibitor of neuronal nitric oxide synthase, a mediator of apoptosis, synaptogenesis, and neuronal development in the brain [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 1546.2), Lung (RPKM 1162.1) and 9 other tissues See more
Orthologs
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Genomic context

See Dynll1 in Genome Data Viewer
Location:
12q16
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41312367..41314742)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47074200..47076573)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene cell wall integrity and stress response component 1-like Neighboring gene serine and arginine rich splicing factor 9 Neighboring gene uncharacterized LOC120096006 Neighboring gene coenzyme Q5, methyltransferase Neighboring gene ring finger protein 10

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC72986

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nitric-oxide synthase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
 
located_in axon cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of cytoplasmic dynein complex TAS
Traceable Author Statement
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein light chain 1, cytoplasmic
Names
8 kDa dynein light chain
8kD LC
dynein LC8
dynein, cytoplasmic, light chain 1
protein inhibitor of neuronal nitric oxide synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053319.3NP_445771.1  dynein light chain 1, cytoplasmic

    See identical proteins and their annotated locations for NP_445771.1

    Status: PROVISIONAL

    Source sequence(s)
    BC063183
    UniProtKB/Swiss-Prot
    P63170
    Related
    ENSRNOP00000061342.1, ENSRNOT00000014910.6
    Conserved Domains (1) summary
    cd21452
    Location:588
    DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    41312367..41314742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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